Over the long term, this research offers possibilities to protect bacteria used in industrial processes against viral infections by giving them a 'flu vaccination'. The researchers will publish their findings in the journal Science on 15 August.
The mechanism that bacteria use to protect themselves against viruses was discovered last year. In an ingenious fashion, the bacteria build pieces of viral DNA into their own DNA. The 'adopted' segment of DNA works like a snapshot in a photo album, a type of memory that reminds the bacteria during a subsequent encounter with the same virus. At that point, the viral DNA is recognised, after which the bacteria set a system into operation that ultimately leads to the breakdown of the virus. Until recently, the operation of this system was a mystery.
The team of researchers from Wageningen, Sheffield (UK) and Bethesda (USA) succeeded in unravelling the operation of this defence system. In recent years, researchers Stan Brouns, Matthijs Jore, Magnus Lundgren and John van der Oost (Laboratory of Microbiology of Wageningen University) identified six bacterial proteins involved in the defence system. These proteins help the bacteria use the built-in virus fragment to prevent a virus infection. The researchers determined that one of the proteins cuts the 'virus snapshot' out of the photo album, and together with the other five proteins, compares the snapshot with the DNA of the invading virus. In the same way, other viruses in the photo album can also be rendered harmless.
With this knowledge, it is theoretically possible to protect bacteria against problematic viruses. This can be compared to a flu vaccination for bacteria. Potential applications include industrial fermentation processes, where bacteria that produce a useful substance are protected against viral infection by means of a 'vaccination' . By reversing the process, the protective mechanism of bacteria can also be deactivated. This could lead to a strategy where viruses can be used to combat bacteria that have developed an advanced form of antibiotic resistance, such as the hospital bacteria.
All animals, plants and bacteria run the risk of being infected by specific viruses. For humans, such viruses include the flu virus, for the tobacco plant this is the tobacco mosaic virus and for the intestinal bacterium E. coli this is the enterobacteria phage lambda. During the course of evolution, these organisms have developed systems to render viruses harmless. Viruses respond by adapting themselves in such a way that they avoid the defence mechanism, to which the bacteria respond in turn. In short, there is a continuous arms race between bacteria and viruses.
Jac Niessen | alfa
Molecular doorstop could be key to new tuberculosis drugs
20.03.2018 | Rockefeller University
Modified biomaterials self-assemble on temperature cues
20.03.2018 | Duke University
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
20.03.2018 | Physics and Astronomy
20.03.2018 | Physics and Astronomy
20.03.2018 | Earth Sciences