Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Going with the flow

12.09.2012
Scientists who study tissue engineering and test new drugs often need to sort, rotate, move, and otherwise manipulate individual cells.

They can do this by prodding the cells into place with a mechanical probe or coaxing them in the desired direction with acoustic waves, electric fields, or flowing fluids.

Techniques that rely on direct physical contact can position individual cells with a high level of precision while non-contact techniques are often faster for sorting large numbers of cells. An international team of researchers has now developed a way to manipulate cells that combines some of the benefits of both contact and non-contact methods.

The researchers suspended a tiny plate in a microfluidic channel and used magnetic controls to move the plate up and down and back and forth. The movements generated fluid flow patterns that varied depending on characteristics of the oscillations such as frequency, magnitude, and phase, and the relative position of the plate and the channel wall.

Changing these parameters allowed the researchers to create different streamlines that either pulled or pushed a cell toward or away from the plate, as well as vortices that rotated the cell. When the cell reached the plate the researchers could also use the plate for precise, direct-contact manipulations.

The researchers demonstrated the technique, which they describe in a paper published in the American Institute of Physics' journal Applied Physics Letters, by manipulating a single bovine egg cell. As a next step, the team plans to demonstrate control of multiple cells simultaneously.

Article: "Local streamline generation by mechanical oscillation in a microfluidic chip for noncontact cell manipulations" is published in Applied Physics Letters.

Link: http://apl.aip.org/resource/1/applab/v101/i7/p074102_s1

Authors: Masaya Hagiwara (1), Tomohiro Kawahara (2, 3), and Fumihito Arai (4)

(1) Aerospace and Mechanical Engineering Department, University of California, Los Angeles
(2) Kyushu Institute of Technology, Japan
(3) Massachusetts Institute of Technology, Cambridge, Mass.
(4) Department of Micro-Nano Systems Engineering, Nagoya University, Japan

Catherine Meyers | EurekAlert!
Further information:
http://www.aip.org

More articles from Life Sciences:

nachricht The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie

nachricht How protein islands form
15.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

Im Focus: Scientists improve forecast of increasing hazard on Ecuadorian volcano

Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).

The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New thruster design increases efficiency for future spaceflight

16.08.2017 | Physics and Astronomy

Transporting spin: A graphene and boron nitride heterostructure creates large spin signals

16.08.2017 | Materials Sciences

A new method for the 3-D printing of living tissues

16.08.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>