Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Examining TLR4 influences of B cell response

Chronic inflammation, which is at the root of multiple diseases, links periodontal disease to increased incidence of cardiovascular disease.

The activation of Toll-Like Receptors, which are essential components of the immune response to certain pathogens, promotes chronic inflammation in periodontal disease.

Of these receptors TLR4 is one of a family of receptors that provides critical links between immune stimulants produced by microorganisms and the host response. It stands out because it plays a key role in systemic inflammation by stimulating a type of white blood cells produced in bone marrow.

Known as B cells they are the cornerstone of the body's antibody production system. The ability of pathogens that chronically infect the mouth to induce TLR4 responses indicates that TLR4 plays a role in the relationship between periodontal disease and cardiovascular disease.

The link between TLR4 activity and periodontal disease, and the importance of B cells in oral immunity prompted a team of Boston University School of Medicine (BUSM) researchers, led by Barbara Nikolajczyk, an associate professor of microbiology and medicine, and her co-investigator, Lisa Gnaley-Leal, an assistant professor of medicine and microbiology, to question whether B cells respond to chronic periodontal disease infection through TLR4.

Tests compared B cells from human blood collected from both healthy volunteers and patients with aggressive periodontitis but no other known disease. The study, published in the Journal of Leukocyte Biology, showed that people with periodontal disease had a higher percentage of peripheral blood and tissue B cells that expressed TLR4. These TLR4-expressing B cells harbored significant changes in the pathways located downstream of TLR4, including unexpected decreases in inflammatory gene expression. Decreased inflammatory gene expression in TLR4-expressing B cells is highly likely to alter the immune responses of periodontal disease patients during inflammation as compared to healthy individuals.

The study highlights two fundamentally different responses by TLR4-expressing cells from periodontal disease patients: activation of monocytes, a type of white blood cell that ingests bacteria and tissue debris, versus inactivation of B cells.

"Overall, these findings demonstrated that the proposed strategy of regulating systemic inflammation disease by regulating TLR4 expression/activation must account for this newly identified source of TLR4 activity, B cells," the study states.

In addition to Nikolajczyk, the authors of the study, "B cells from periodontal disease patients express surface Toll-like receptor 4,"are Hyunjin Shin, research assistant, and Yue Zhang, research associate, of the BUSM's department of microbiology, Madhumita Jagannathan, a graduate research assistant, at BUSM's Pathology Department, and Hatice Hasturk, Alpdogan Kantarci, both assistant professors and research assistant Hongsheng Liu and Professor Thomas E. Van Dyke, of the Department of Periodontology and Oral Biology at Boston University's Goldman School of Dental Medicine.

Gina DiGravio | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>