One of these researchers is Padma Rajagopalan, director of the Virginia Tech Institute of Critical Technology and Applied Science’s Center for Systems Biology of Engineered Tissues. She is a past recipient of a National Science Foundation CAREER Award to fund her work on cell migration, and in the past two years she has received more than $1 million in funding to create and study engineered tissues that mimic the human liver.
Now, the U.S. Environmental Protection Agency has awarded one its three-year $750,000 Science to Achieve Results award that it calls STAR to Rajagopalan of chemical engineering and core faculty in the School of Biomedical Engineering and Sciences. T.M. Murali of Virginia Tech’s Department of Computer Science is a co-principal investigator on this award and is also co-director of the systems biology center. Marion Ehrich of the Virginia-Maryland Regional College of Veterinary Medicine and co-director of its Laboratory for Neurotoxicity Studies will serve as a consultant on the project.
The newly funded work will take advantage of Rajagopalan’s in vitro three-dimensional liver mimic, an engineered functional tissue. Since the liver plays a central role in the detoxification of the human body, the new project will establish this liver mimic as an effective model for studying the effects of different types of toxins on the liver.
Rajagopalan said, “With the increasing number of chemicals, such as pesticides, being used in agriculture and industry today, humans are exposed to these substances to much greater extents. However, we lack a comprehensive understanding of the cell-and organ-wide effects of mixtures of toxic substances and how interactions among them can lead to chronic health problems. These gaps in our knowledge pose fundamental barriers to preventing or mitigating life-threatening toxicant-induced health issues.”
This award will specifically look at chemically-driven liver damage resulting from exposure to carbon tetrachloride, found in cleaning agents among other products, and to dichloroethylene, used as a solvent in floor finishes such as waxes and lacquers, among other purposes.
With Murali’s expertise in computer science and bioinformatics , they will be able to establish a combined experimental and computational pipeline for toxicity testing and risk assessment based on three-dimensional liver mimics and biological process linkage networks.
Lynn Nystrom | Newswise Science News
CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften
Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
19.01.2017 | Ecology, The Environment and Conservation
19.01.2017 | Awards Funding
19.01.2017 | Studies and Analyses