Allergy to pollen of common ragweed is increasingly affecting patients and is second only to grass pollen in terms of incidence in the general population of many European countries.
An Italian team led by Giovanni Appendino and Orazio Taglialatela-Scafati has now taken the first steps to investigate the phytochemical profile of the European population of A. artemisiifolia and studied its activation of TRPA1, a major player in the induction of airways inflammatory reactions. As the scientists report in the European Journal of Organic Chemistry, their findings help to better understand the increasing problem of sensitization to Ambrosia pollen.
Surprisingly, limited information exists on the phytochemistry of common ragweed (Ambrosia artemisiifolia L.), despite the potential involvement of non-protein constituents in the unusual severity of the allergic reactions induced by its pollen. A. artemisiifolia is an invasive species native to North America, but it is nowadays widespread in most temperate regions of the world.
The pollen from A. artemisiifolia induces respiratory symptoms ranging from rhinitis and rhinoconjunctivitis to asthma in a growing share of the population, with increasing economic costs to public health systems. The pollen grains are small and light and are easily subjected to long distance transport.
As such, they can also deeply penetrate the aerial pathways, inducing local irritation. The Italian team collected samples near Novara, Italy, and along with some already known compounds, eight novel sesquiterpenoids were isolated from the aerial parts of A. artemisiifolia. TRPA1 (a polymodal sensor) is highly expressed in the aerial pathways and is associated with irritation induced by airborne contaminants and the induction of asthmatic crises. In a previous study, an excellent correlation was found between the activation of TRPA1 and Michael reactivity, as determined by a cysteamine NMR assay. Thus, after identification of the new compounds, their Michael activity and their ability to activate TRPA1 were investigated.
The authors found that some of the electrophilic terpenoids from A. artemisiifolia behaved as potent activators of TRPA1, and that the pollen contained high concentrations of this type of compound, some of which are well-known skin allergens. Interestingly, they also found that the cysteamine assay showed discrimination between structurally related electrophilic compounds, which is important in identifying the most potent allergens present in the mixture extracted from the plant. The scientists’ results help to understand the pathogenesis of allergy to common ragweed, highlighting the potential role of electrophilic terpenoids in this pathology.
European Journal of Organic Chemistry, Permalink to the article: http://dx.doi.org/10.1002/ejoc.201200650
Giovanni Appendino | Wiley-VCH
A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences