Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Double Strike To Fight Cancer

01.03.2011
Combined diagnosis and treatment of tumors: photothermically activated ultrasound contrast agent

Diagnosis and treatment form the basis of modern medicine. Traditionally, they are two separate steps; however, it doesn’t have to be that way.

The term “theranostic” refers to the combination of a diagnostic test with a specific treatment based on the result of the test. This integrated approach should be particularly helpful in providing more targeted treatment for cancer patients. In the journal Angewandte Chemie, a research team headed by Zhifei Dai at the Harbin Institute of Technology (China) has now introduced a new theranostic agent that simultaneously serves as a contrast agent for ultrasound imaging and as a drug for the photothermic treatment of tumors.

Ultrasound imaging is a safe and inexpensive diagnostic tool that delivers images in real time. A probe sends out short, directional bursts of sound waves, which are reflected and diffracted differently in the different layers of tissue. Suitable contrast agents, such as tiny gas bubbles, can significantly improve the sensitivity and resolution of the images.

The Chinese researchers wished to develop a new contrast agent that simultaneously acts as a drug for photothermic treatment. In this method of treatment, an agent, such as gold nanoshells, is selectively introduced into a tumor, and this region is then irradiated. This causes the gold particles to become very hot, overheating the diseased tissue and causing it to die off. Gold nanostructures can be made to specifically absorb near-infrared light, a wavelength that can penetrate deep into tissues without causing damage.

For their new theranostic agent, the scientists used a biocompatible polymer to produce nanocapsules containing tiny drops of water. They coated the capsules with gold and removed the water through freeze-drying. This produced tiny air-filled cavities within the microcapsules. These are the contrast agent for the ultrasound; the gold shell acts as the photothermically activated drug.

In animal trials, the new multifunctional agent proved to be nontoxic and demonstrated very good contrast enhancement in ultrasound examinations. When cultures of tumor cells were treated with the microcapsules, the cells could be killed off through irradiation.

“With our new therapeutic contrast agent, we were able to locate the tumor by ultrasound imaging and determine its size,” explains Dai. “With real time monitoring, the tumor could then be irradiated, successful treatment confirmed, and healthy tissue protected.”

Author: Zhifei Dai, Harbin Institute of Technology (China), http://nanobio.hit.edu.cn/CV_DaiZF_EN.html

Title: Gold Nanoshelled Microcapsules Operate as Theranostic Agent for Ultrasound Contrast Imaging and Photothermal Therapy

Angewandte Chemie International Edition, Permalink to the article: http://dx.doi.org/10.1002/anie.201008286

Zhifei Dai | Angewandte Chemie
Further information:
http://nanobio.hit.edu.cn/CV_DaiZF_EN.html
http://pressroom.angewandte.org

More articles from Life Sciences:

nachricht More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>