Food insecurity is driving the search for ways to increase the amount of food we grow, whilst at the same time reducing unsustainable agricultural inputs. One way to do this is to increase the innate ability of crops to fight off disease-causing pathogens. Increased disease resistance would reduce yield losses as well as reduce the need for pesticide spraying.
Breeding programs for resistance generally rely on single resistance genes that recognise molecules specific to particular strain of pathogens. Hence this kind of resistance rarely confers broad-spectrum resistance and is often rapidly overcome by the pathogen evolving to avoid recognition by the plant.
However, plants have another defence system, based on pattern recognition receptors (PRRs). PRRs recognise molecules that are essential for pathogen survival. These molecules are less likely to mutate without harming the pathogen's survival, making resistance to them more durable in the field. These essential molecules are common to many different microbes, meaning that if a plant recognises and can defend itself against one of these molecular patterns, it is likely to be resistant against a broad range of other pathogens.
Very few of these PRRs have been identified to date. Dr Cyril Zipfel and his group at the Sainsbury Laboratory in Norwich, UK, took a Brassica-specific PRR that recognises bacteria, and transformed it into the Solanaceae plants Nicotania benthaminia and tomato.
"We hypothesised that adding new recognition receptors to the host arsenal could lead to enhanced resistance," said Dr Zipfel.
Under controlled laboratory conditions, they tested these transformed plants against a variety of different plant pathogens, and found drastically enhanced resistance against many different bacteria, including some of great importance to modern agriculture such as Rastonia solanaceraum, the causal agent of bacterial wilt and a select agent in the United States under the Agricultural Bioterrorism Protection Act of 2002.
"The strength of this resistance is because it has come from a different plant family, which the pathogen has not had any chance to adapt to. Through genetic modification, we can now transfer this resistance across plant species boundaries in a way traditional breeding cannot," said Dr Zipfel.
Published in the journal Nature Biotechnology, the finding, that plant recognition receptors can be successfully transferred from one plant family to another provides a new biotechnological solution to engineering disease resistance. The Zipfel group is currently extending this work to other crops including potato, apple, cassava and banana that all suffer from important bacterial diseases, particularly in the developing world.
"A guiding principle in plant pathology is that most plants tend to be resistant to most pathogens. Cyril's work indicates that transfer of genes that contribute to this basic innate immunity from one plant to another can enhance pathogen resistance," commented Professor Sophien Kamoun, Head of the Sainsbury Laboratory. "The implications for engineering crop plants with enhanced resistance to infectious diseases are very promising."
This research was funded by the Gatsby Charitable Foundation and the Two Blades Foundation, who have patented the technology on behalf of the inventors, and involved research groups from INRA/CNRS in France, the University of California, Berkeley and Wageningen University in the Netherlands.Contacts:
About The Sainsbury Laboratory http://www.tsl.ac.uk
The Sainsbury Laboratory (TSL) is a world-leading research centre focusing on making fundamental discoveries about plants and how they interact with microbes. TSL is evolving its scientific mission so that it not only provides fundamental biological insights into plant-pathogen interactions, but also delivers novel, genomics-based, solutions which will significantly reduce losses from major diseases of food crops, especially in developing countries.
About The Two Blades Foundation http://www.2blades.org/
The Two Blades Foundation (2Blades) supports the development of durable disease resistances in crop plants and their deployment in agriculture. 2Blades is a US-based charitable organization that supports programs of research and development on durable disease resistance. Where research identifies ways of breeding for lasting resistance, 2Blades seeks to promote their deployment in practical programs of crop improvement. 2Blades aims to support the use of safe, environmentally-benign and sustainable strategies for crop production so as to provide long-term protection from crop losses due to plant disease. The Foundation recognises that there is an especially urgent need for the development of disease resistant crops in less developed and subsistence agricultures and consequently this is a major focus of its activity.
About the Gatsby Charitable Foundation: http://www.gatsby.org.uk/
Andrew Chapple | EurekAlert!
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy