Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New data on the breakdown of the KRas protein

22.04.2009
KRas is one of the usual suspects in cancer. It is a protein that is mutated in 30% of human tumors and has been implicated in the regulation of many cell signalling pathways.

For this reason, it is one of the main focuses of attention of international basic research and it is difficult to publish new information relating to its molecular biology.

Researchers from the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and the University of Barcelona (UB) have discovered a new breakdown pathway for this protein. The results, which could mean a new form of signalling involving KRas, were published in the latest edition of the Journal of Cell Biology (184(6):863-79), where they merited an appearance on the front page of the journal and an editorial comment.

This study is part of the doctoral thesis of Dr. Albert Lu and includes the participation of Dr. Oriol Bachs, Dr. Carles Enrich, Dr. Neus Agell and Dr. Francesc Tebar, researchers from IDIBAPS and the Department of Cell Biology, Immunology and Neuroscience of the Faculty of Medicine of the University of Barcelona. Researchers from the University of Kyoto also took part in the study.

The article describes how the KRas protein is actively transported from the cell membrane, where most of its known activity takes place, to the lysosomes. The lysosomes are organelles responsible for breaking down proteins; this breakdown pathway was unknown in the case of KRas. Thanks to videomicroscopy techniques using a confocal microscope and the fluorescence, resonance energy transfer (FRET) technique, the researchers have observed how the protein is brought inside the cell and transported to the lysosomes. The protein remains active during this journey through the interior of the cell, which leads to the suspicion that it continues to exercise its influence on signalling pathways relating to cell proliferation and the appearance of cancers.

The signalling pathways activated by KRas are highly complex. With the newly available data, it will be necessary to investigate whether the signals emitted on the way to the lysosomes have a different meaning for the cell than those generated from the membrane, the protein’s usual site of action.

These results provide clues to stimulating the elimination of KRas, a line of research that might result in new therapeutic strategies against cancer and diseases in which the formation of lysosomes is abnormal, such as Niemann-Pick disease. KRas is already used in the diagnosis of diseases such as colon, lung and breast cancer. The better we understand its biology, the more we will know about how it appears and how this and other diseases can be combatted.

Alex Argemi | EurekAlert!
Further information:
http://www.clinic.ub.es

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>