Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Crossing the line

06.09.2010
Understanding of blood cell lineages advances with the discovery of a transcription factor crucial to T cell differentiation

A master gene that underpins the development of specific blood cell lineages has been identified by a research team led by Hiroshi Kawamoto at the RIKEN Research Center for Allergy and Immunology in Yokohama. The team has published its findings in the journal Science1.

Precursor cells in the immune system, known as hematopoietic progenitor cells, can give rise to multiple immune cell types. Kawamoto and his team cultured multipotent progenitor cells from mice that could become T cells that shape the immune response, B cells that generate antibodies, or myeloid cells that can engulf pathogens. Their special culture system could stimulate the Notch signaling pathway, which is required for progenitor cell renewal, and included immune system regulators such as interleukin-7 (IL-7).

The researchers found they could induce the immune progenitor cells to lose their ability to become B cells under these conditions. However, this halted development of the cells past this stage, as the progenitors were unable to cease proliferating and mature into either T cells or myeloid cells.

Kawamoto and colleagues then observed that removing IL-7 from the cell culture medium was sufficient to drive the progenitors to mature into T cells. They found that withdrawing IL-7 induced the expression of the transcription factor Bcl11b, which is known to be expressed in T cells. Interestingly, even when IL-7 was present in the cell culture medium, they could push immune progenitor cells into becoming T cells by forcing Bcl11b to be expressed in the cells. This suggested to the researchers that this transcription factor drives this step in the commitment of these immune progenitor cells to the T cell lineage.

The team also showed that progenitor cells lacking the Bcl11b gene were unable to mature into T cells, and could continue to proliferate (Fig. 1). This is consistent with previous findings by other research teams that disruption of the function of Bcl11b is linked to leukemia and lymphoma, which may be caused by the inability of the progenitor cells to mature properly into T cells, and to instead continue to proliferate. Kawamoto and his colleagues think that Bcl11b may drive progenitor cells to take on the T cell fate by suppressing the genes that characterize the myeloid cell lineage.

“Our findings may facilitate the study of the molecular mechanisms of T cell lineage commitment by elucidating the exact timing for this commitment,” explains Kawamoto, “and by identifying a master gene for the establishment of T cell lineage.”

The corresponding author for this highlight is based at the Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology

Journal information

1. Ikawa, T., Hirose, S., Masuda, K., Kakugawa, K., Satoh, R., Shibano-Satoh, A., Kominami, R., Katsura, Y. & Kawamoto, H. An essential developmental checkpoint for production of the T cell lineage. Science 329, 93–96 (2010).

gro-pr | Research asia research news
Further information:
http://www.rikenresearch.riken.jp/eng/research/6380
http://www.researchsea.com

More articles from Life Sciences:

nachricht New gene catalog of ocean microbiome reveals surprises
18.08.2017 | University of Hawaii at Manoa

nachricht Organ Crosstalk: Fatty Liver Can Cause Damage to Other Organs
18.08.2017 | Deutsches Zentrum für Diabetesforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New gene catalog of ocean microbiome reveals surprises

18.08.2017 | Life Sciences

Astrophysicists explain the mysterious behavior of cosmic rays

18.08.2017 | Physics and Astronomy

AI implications: Engineer's model lays groundwork for machine-learning device

18.08.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>