Infections following treatment in clinics, retirement homes, and long-term care facilities are a grave problem for patients, and resistant germs can be particularly devastating.
“High infection rates are in particular observed related to implants, catheters, and stents,” reports Karl Gademann, “those for urinary catheters mounting up to 30 % per week!” In cooperation with his team at the Swiss Federal Institute of Technology in Lausanne, he has developed a process for coating surfaces with an antimicrobial layer. As reported in the journal Angewandte Chemie, their system is based on hybrid molecules derived from various natural products.
For a patient, the results are particularly grave if an infection occurs in an implant. Usually, replacement of the affected part is the only possible treatment. “One particularly attractive approach is the application of antibiotics directly on the material,” says Gademann. To test their idea, the team from Lausanne chose to use natural product hybrids: biologically active fragments of various natural products are coupled to combine two different modes of action.
The hybrid produced by Gademann’s team is made of three parts: two natural products are coupled by means of a polymer bridge. The first substance is anachelin, an iron transporter (siderophore) from cyanobacteria. Anachelin strongly and selectively binds metal oxides. The majority of implants are made from a metal oxide: highly biocompatible titanium dioxide. Anachelin fixes the hybrid firmly to the surface of the implant. The second natural product is the antibiotic vancomycin, which disrupts the biosynthesis of cell walls and thus stops bacterial growth. The coupling component is polyethylene glycol, a chemically inert, nontoxic polymer. It also assures that dead bacteria and cell components cannot bind to the surface.
The hybrid can be applied to titanium dioxide components in a simple dunking procedure. “We were able to demonstrate that our hybrid firmly attaches to titanium dioxide surfaces and effectively hinders infection with Bacillus subtilis as well as the attachment of cellular material,” says Gademann.
| Angewandte Chemie International
What the world's tiniest 'monster truck' reveals
23.08.2017 | American Chemical Society
Treating arthritis with algae
23.08.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
23.08.2017 | Life Sciences
23.08.2017 | Life Sciences
23.08.2017 | Physics and Astronomy