Children and adolescents suffering from attention deficit hyperactivity disorder (ADHD) have a lower risk of traumatic brain injury when taking methylphenidate or atomoxetine. This was shown in a longitudinal study of ADHD in children and adolescents in Germany performed by the Leibniz Institute for Prevention Research and Epidemiology - BIPS and funded by the German Federal Ministry of Education and Research. Results of the project have now been published in the American journal JAMA Pediatrics.
It is well known that people with ADHD suffer more often from accidental injuries such as fractures, head injuries, burns, and poisoning. However, until now, there was no clear evidence that therapy with methylphenidate or atomoxetine could reduce the increased risk of injury.
Scientists from the Leibniz Institute for Prevention Research and Epidemiology - BIPS and the Helmholtz Centre for Infection Research investigated this question in their study of children and adolescents with ADHD.
The study was based on the German Pharmacoepidemiological research database (GePaRD) with data from about 17 million insured persons from four statutory health insurance providers in Germany. The researchers identified 37,650 children and adolescents between the ages of three and 17 years newly diagnosed with ADHD in 2005 and 2006.
In this group, which was followed until 2009, 2,128 children and adolescents were hospitalized for injuries, including 821 with a diagnosis of traumatic brain injury.
For the 2,128 children and adolescents treated with an injury in hospital, the researchers recorded all prescriptions of methylphenidate and atomoxetine. It was found that just over half of them received a prescription of methylphenidate or atomoxetine during the observation period; 92 percent of the prescriptions were for methylphenidate. The researchers then compared the general risk of an injury or a traumatic brain injury under drug treatment during the observation period to the risk without treatment.
It was found that during drug treatment the probability of being admitted to hospital for traumatic brain injury was lower by 34 percent. However, if all injuries resulting in hospitalization were considered, the risk reduction did not reach statistical significance.
Prof. Dr. Edeltraut Garbe, head of the Department of Clinical Epidemiology at BIPS, explains: "Our study results indicate that children and adolescents with ADHD have a lower risk of traumatic brain injury if they are treated with methylphenidate or atomoxetine. Whether this is true for accidental injuries in general must be investigated further - our study suggests, but could not prove, this."
Mikolajczyk R, Horn J, Schmedt N, Langner I, Lindemann C, Garbe E. Accident prevention by medication among children with attention deficit/hyperactivity disorder (ADHD) - A case-only study. JAMA Pediatrics. 2015; http://dx.doi.org/10.1001/jamapediatrics.2014.3275
Leibniz Institute for Prevention Research and Epidemiology - BIPS
Department of Clinical Epidemiology
Prof. Dr. Edeltraut Garbe
Press office BIPS
Anja Wirsing | idw - Informationsdienst Wissenschaft
Funding of Collaborative Research Center developing nanomaterials for cancer immunotherapy extended
28.06.2017 | Johannes Gutenberg-Universität Mainz
Zeolite catalysts pave the road to decentral chemical processes Confined space increases reactivity
28.06.2017 | Technische Universität München
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
28.06.2017 | Physics and Astronomy
28.06.2017 | Physics and Astronomy
28.06.2017 | Health and Medicine