Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Canine compulsive disorder gene identified in dogs

07.01.2010
Gene shares family with recently targeted gene for autism

A canine chromosome 7 locus that confers a high risk of compulsive disorder susceptibility has been identified through a collaboration between the Behavior Service at the Cummings School of Veterinary Medicine, the Program in Medical Genetics at the University of Massachusetts Medical School and the Broad Institute at the Massachusetts Institute of Technology. The findings are published in the January 2010 edition of Molecular Psychiatry.

Obsessive compulsive disorder is characterized by time consuming, repetitive behaviors and affects about 2 percent of humans, while the equally distressing canine equivalent, canine compulsive disorder, or CCD, seems to target certain dog breeds, especially Dobermans and Bull Terriers. For over a decade, behaviorists Drs. Dodman and Moon-Fanelli, at Tufts Cummings School of Veterinary Medicine collected blood samples from carefully characterized Doberman patients exhibiting flank- and/or blanket-sucking compulsive behaviors, as well as healthy, unaffected Doberman. In 2001, Edward Ginns, PhD, MD, head of the Program in Medical Genetics at UMass Medical School, joined the effort, enabling genetic studies that culminated in the genome wide association study that began in 2007 using the canine Affymetrix genotyping array at the Broad Institute.

The chromosome 7 location most significantly associated with CCD is located within the neural cadherin-2 gene, CDH2. CDH2 is widely expressed, mediating synaptic activity-calcium flux related neuronal adhesion. Dogs showing multiple compulsive behaviors had a higher frequency of the "risk" associated DNA sequence than dogs with a less severe phenotype (60 and 43%, respectively, compared with 22% in unaffected dogs). This highly significant association of CCD with the CDH2 gene region on chromosome 7 is the first genetic locus identified for any animal compulsive disorder, and raises the intriguing possibility that CDH2 and other neuronal adhesion proteins are involved in human compulsive behaviors, including those observed in autism spectrum disorder. The neural cadherin-2 gene, CDH2, is an especially attractive candidate disease gene as it is involved in mediating presynaptic to postsynaptic neuronal junction adhesion, neuronal axon outgrowth and guidance in the central nervous system during development when critical brain nerve networks are established.

"The CDH2 gene is expressed in the hippocampus, a brain region suspected to be involved in OCD. In addition, this gene oversees structures and processes that are possibly instrumental in propagating compulsive behaviors - for example, the formation and proper functioning of glutamate receptors," said Dr. Nicholas Dodman, professor of clinical sciences at Cummings School of Veterinary Medicine at Tufts University and the study's lead author. Dr. Dodman added that "this finding is congruent with current evidence that NMDA blockers are effective in the treatment of OCD."

"The occurrence of repetitive behaviors and similarities in response to drug treatments in both canine CCD and human OCD suggest that common pathways are involved" said Dr. Ginns, professor of Clinical Pathology, Neurology, Pediatrics, Psychiatry and Neuroscience at UMass Medical School. Dr. Ginns is hopeful that "our finding will lead to a better understanding of the biology of compulsive disorder and facilitate development of genetic tests, enabling earlier interventions and even treatment or prevention of compulsive disorders in at-risk canines and humans." "This lead is so intriguing that we look forward to working with Dr. Dodman's group to extend our current findings to other populations." added Dr. Marzena Galdzicka, assistant professor of Clinical Pathology at UMass Medical School. Collaborations are already in progress with Dr. Dennis Murphy's group at the National Institute of Mental Health to determine the extent to which CDH2 confers risk for human OCD and autism spectrum disorders.

Cummings School of Veterinary Medicine at Tufts University

Founded in 1978 in North Grafton, Mass., Cummings School of Veterinary Medicine at Tufts University is internationally esteemed for academic programs that impact society and the practice of veterinary medicine; three hospitals and two clinics that combined treat more than 80,000 animals each year; and groundbreaking research that benefits animal, public, and environmental health.

About the University of Massachusetts Medical School

The University of Massachusetts Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research institution, consistently producing noteworthy advances in clinical and basic research. The Medical School attracts more than $240 million in research funding annually, 80 percent of which comes from federal funding sources. The mission of the Medical School is to advance the health and well-being of the people of the commonwealth and the world through pioneering education, research, public service and health care delivery with its clinical partner, UMass Memorial Health Care. For more information, visit www.umassmed.edu.

Tom Keppeler | EurekAlert!
Further information:
http://www.tufts.edu
http://www.umassmed.edu

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>