Their findings have been published in the current issue of Science Express, an online publication of selected papers in advance of the print edition of Science, the main journal of the American Association for the Advancement of Science (AAAS).
"Wolbachia are widespread, maternally-transmitted intracellular bacteria that infect most insect species and are able to alter the reproduction of innumerous hosts," said Horacio Frydman, assistant professor of biology at Boston University and the study's principal investigator. "An important aspect of this relationship is that Wolbachia often alter their host's reproductive ability, yet very little is known about how this is achieved." In this paper, PhD student Eva Fast and her colleagues in the Frydman lab describe a study in Drosophila mauritiana that offers insights into the cellular mechanisms through which Wolbachia upregulates egg production by their hosts.
Specifically, the BU team demonstrate that Wolbachia in D. mauritiana have a remarkable tropism for terminal filament and cap cells in the female germline stem cell (GSC) niche (and a similar tropism in hub cells, the male GSC niche). They also show through extensive analysis of proliferation and cell death markers in multiple experiments that infected D. mauritiana have higher rates of GSC division and lower rates of germline cyst death in the germarium relative to uninfected counterparts. Finally, they provide compelling evidence suggesting that Wolbachia affects GSC division through effects on the niche. "Knowledge emerging from this research will be relevant for the basic stem cell biology as well for the development of cell biological strategies for disease control," said Frydman.
About Boston University—Founded in 1839, Boston University is an internationally recognized private research university with more than 30,000 students participating in undergraduate, graduate, and professional programs. As Boston University's largest academic division, the College and Graduate School of Arts & Sciences is the heart of the BU experience with a global reach that enhances the University's reputation for teaching and research.Contact information for the authors:
Patrick Farrell | EurekAlert!
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences