From bird flu to the West Nile virus, bird diseases can have a vast impact on humans. Thus, understanding bird immune systems can help people in a variety of ways, including protecting ourselves from disease and protecting our interests in birds as food animals.
An important element in the immune system of many animals’ immune systems—including mammals, reptiles, amphibians, and most animals with a backbone—is a protein called tristetraprolin, or TTP. TTP plays an anti-inflammatory role, largely through keeping another protein, called tumor necrosis factor alpha (TNF), in check.
Studies have shown that mice bred without TTP develop chronic inflammation that affects their entire bodies. Even animals missing TTP in just one immune cell type develop a catastrophic and deadly inflammation when they’re exposed to tiny amounts of a molecule from bacteria, underlying the importance of this protein. And yet, researchers have not been able to find TTP in birds.
Could birds really be that different from the vast majority of their closest animal relatives? To answer that question, researcher Perry Blackshear and his colleagues at the National Institute of Environmental Health Sciences conducted a comprehensive examination, using several different methods to look for TTP in birds. Their results suggest that birds are truly an anomaly, having no analog for TTP in their immune systems.
Their article is entitled “Life Without TTP: Apparent Absence of an Important Anti-Inflammatory Protein in Birds” (http://bit.ly/1afLzwl). It appears in the Articles in PresS section of the American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology, published by the American Physiological Society.Methodology
“From an immunological standpoint,” the authors say, “it will be both interesting and important to determine how birds cope differently with the environmental and microbiological assaults that stimulate the acute innate immune response in mammals. This will be important to understand, both to protect birds from infections, and to protect man from bird-transmitted” viruses.Study Team
Donna Krupa | Newswise
Further reports about: > Comparative Physiology > Environmental Health Sciences > Health Sciences > Integrative Medizin > Protein > TTP > Tristetraprolin > West Nile virus > anti-inflammatory > bird diseases > bird genomes > environmental risk > immune cell > immune system > regulatory > tumor necrosis factor
Cells communicate in a dynamic code
19.02.2018 | California Institute of Technology
Studying mitosis' structure to understand the inside of cancer cells
19.02.2018 | Biophysical Society
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
19.02.2018 | Materials Sciences
19.02.2018 | Materials Sciences
19.02.2018 | Life Sciences