Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Biomarker Test Predicts Arthritis at Much Earlier Stage, MU Researchers Say

16.05.2012
Early detection system would allow better treatment options

More than 27 million adults currently suffer from osteoarthritis, which is the most common form of arthritis. In the past, doctors have been unable to diagnose patients with arthritis until they begin to show symptoms, which include joint pain and stiffness.

By the time these symptoms are present, it is often too late for preventive and minimally invasive treatment options to be effective. Now, a research team from the University of Missouri’s Comparative Orthopaedic Laboratory has found a way to detect and predict arthritis before patients begin suffering from symptoms.

James Cook, a researcher from the MU College of Veterinary Medicine and the William C. and Kathryn E. Allen Distinguished Professor in Orthopaedic Surgery, along with MU researchers Bridget Garner, Aaron Stoker, Keiichi Kuroki, Cristi Cook, and Prakash Jayabalan, have developed a test using specific biomarkers that can accurately determine if a patient is developing arthritis as well as predict the potential severity of the disease. The test can be run off of a single drop of fluid from a patient’s joint, which is obtained with a small needle similar to drawing blood.

“With this biomarker test, we can study the levels of specific proteins that we now know are associated with osteoarthritis,” Cook said. “Not only does the test have the potential to help predict future arthritis, but it also tells us about the early mechanisms of arthritis, which will lead to better treatments in the future.”

In their study published in the Journal of Knee Surgery, the MU researchers report that they developed the test by analyzing the joints of dogs that suffer from arthritis. Veterinarians predict that 20 percent of middle-aged dogs and 90 percent of older dogs have osteoarthritis in one or more joints. Since canine joints operate similarly to the joints of humans, Cook says the test is being adapted to human patients.

“This test has already shown early usefulness for allowing us to monitor how different treatments affect the arthritic joints in people,” Cook said. “With further validation, this test will allow doctors to adjust and fine tune treatments to individual patients. Also, being able to tell patients when they are at a high risk for developing arthritis will give doctors a strong motivational tool to convince patients to take preventive measures including appropriate exercise and diet change.”

The biomarker test is currently available for licensing and is in the process of gaining FDA approval.

This study is a result of collaboration through Mizzou Advantage, a program that focuses on four areas of strength at MU: food for the future, media of the future, one health/one medicine, and sustainable energy. The goals of Mizzou Advantage are to strengthen existing faculty networks, create new networks and propel Mizzou’s research, instruction and other activities to the next level. The Mizzou Advantage was created to increase MU’s visibility, impact and stature in higher education, locally, statewide, nationally and around the world.

Nathan Hurst | EurekAlert!
Further information:
http://www.missouri.edu

Further reports about: Arthritis Biomarker Cook Orthopaedic Prostate Surgery Stage Acting specific protein

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>