Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Barshop Institute, global team sequences DNA of naked mole rat

13.10.2011
San Antonio colony of long-lived rodents contributes to study published in Nature

Scientists have sequenced the complete genome of the naked mole rat, a pivotal step to understanding the animal's extraordinarily long life and good health. A colony of more than 2,000 naked mole rats at The University of Texas Health Science Center at San Antonio contributed to the findings, published today in the journal Nature.

"If we understand which genes are different or are expressed differently in naked mole rats — compared to short-lived mice that clearly have poor defenses against aging and cancer — we might find clues as to why the naked mole rat is able to extend both health span and longevity, as well as fight cancer, and this information could be directly relevant and translatable to humans," said Rochelle Buffenstein, Ph.D., professor of physiology at the Barshop Institute for Longevity and Aging Studies, part of the UT Health Science Center San Antonio. Dr. Buffenstein worked on the study with Thomas Park, Ph.D., of the University of Chicago; Vadim Gladyshev, Ph.D., of Harvard Medical School; the Beijing Genomics Institute; and other collaborators.

Rodent Methuselahs

The mouse-sized naked mole rat is the longest-lived rodent known, surviving up to 31 years in captivity. This is much longer than its laboratory rodent relatives, and the naked mole rat maintains good health and reproductive potential well into its third decade. Naked mole rats live underground in large family groups, like termites and bees, with only a single breeding female. These social rodents are extremely tolerant of life in low oxygen and high levels of carbon dioxide.

The naked mole rat's capacity to resist cancer and maintain protein integrity in the face of oxidative damage makes it an ideal animal model for aging and biomedical research, Dr. Buffenstein said. "Deciphering the animal's genetic blueprint is an important step to unlocking the keys to the naked mole rat's extraordinary longevity," she said. "This study reveals many of the genetic secrets to their extraordinary longevity, cancer resistance and pain tolerance, and their ability to survive in a low-oxygen environment. Indeed, having this animal's genetic blueprint is a treasure trove for many areas of biology and medicine because the genome will now be available to scientists everywhere to explore in their favored research area."

Barshop Institute Director Arlan Richardson, Ph.D., said: "The data in this Nature paper are very important for aging research because they give us the first glimpse into how the naked mole rat lives 10 times longer than its distant cousins, the mouse and rat."

Unusual appearance

Naked mole rats resemble pink, saber-toothed "sausages." Previous studies have yielded important insights into how the naked mole rat is able to rewire its brain (a process called neural plasticity), tolerate low oxygen and low body temperatures, and show cancer-free good health well into old age.

"Understanding their genomic footprint may reveal how they are able to maintain the integrity of their proteins and DNA far better than other animals do in old age, as well as how they mitigate the translation of oxidative damage into age-related declines and disease," Dr. Buffenstein said.

For current news from the UT Health Science Center San Antonio, please visit our news release website or follow us on Twitter @uthscsa.

About the UT Health Science Center San Antonio

The University of Texas Health Science Center at San Antonio, one of the country's leading health sciences universities, ranks in the top 3 percent of all institutions worldwide receiving federal funding. Research and other sponsored program activity totaled $228 million in fiscal year 2010. The university's schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced approximately 26,000 graduates. The $744 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg. For more information on the many ways "We make lives better®," visit www.uthscsa.edu.

Will Sansom | EurekAlert!
Further information:
http://www.uthscsa.edu

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>