Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bacteria possible cause of preterm births

28.01.2011
The type of bacteria that colonize the placenta during pregnancy could be associated with preterm birth and other developmental problems in newborns according to research published in the current issue of the online journal mBio®.

"The fetal inflammatory response appears to contribute to the onset of preterm labor, fetal injury and complications, underlying lifetime health challenges facing these children," say the researchers from Harvard Medical School, Brigham and Women's Hospital and Children's Hospital of Boston. "Our data suggest that placental colonization by specific groups of organisms can increase or decrease the risk of a systemic inflammatory condition."

Preterm birth occurs in nearly a half million pregnancies in the United States alone. Despite improved care, preterm and especially extremely low-gestational-age newborns continue to be at a considerably higher risk of morbidity, mortality and developmental problems. Much of this risk is attributable to imbalanced inflammatory responses of the fetus and newborn.

The systemic fetal inflammatory response to intrauterine exposures, especially intrauterine infections, is regarded as an important contributor to the onset and often lifelong consequences of preterm labor, fetal injury and early organ damage. Approximately half of all placentas delivered before the second trimester and 41% of those delivered by Caesarean section harbor microorganisms detectable by culture techniques.

In order to better understand what role, these microorganisms could play in the extremely preterm inflammatory response the researchers analyzed protein biomarkers in dry blood spots obtained from 527 newborns delivered by Caesarean section and cultured and identified the bacteria from their respective placentas.

Placentas colonized primarily by microorganisms commonly associated with the condition know as bacterial vaginosis (BV) were found to be associated with elevated levels of proinflammatory protein in newborns. In contrast, colonization by Lactobacillus species of bacteria (often found in decreased concentrations during BV) were associated with lower levels of proinflammatory proteins.

"Our study supports the concept that the placental colonization with vaginal microorganisms can induce a systemic inflammatory response in the fetus and newborn and that the dominating molecular feature of this response can be dependent on the type of bacteria," says Andrew Onderdonk of Harvard Medical School and Brigham and Women's Hospital, one of the authors of the study. "Our data suggest that the targeting of placental colonization by specific drugs or probiotics during early pregnancy may hold promise for preventing not only preterm birth but also the devastating and far-reaching inflammatory consequences in premature newborns."

mBio® is a new open access online journal published by the American Society for Microbiology to make microbiology research broadly accessible. The focus of the journal is on rapid publication of cutting-edge research spanning the entire spectrum of microbiology and related fields. It can be found online at http://mbio.asm.org.

The journal article can be found online at http://mbio.asm.org/content/2/1/e00280-10

Jim Sliwa | EurekAlert!
Further information:
http://www.asmusa.org

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Solar Collectors from Ultra-High Performance Concrete Combine Energy Efficiency and Aesthetics

16.01.2017 | Trade Fair News

3D scans for the automotive industry

16.01.2017 | Automotive Engineering

Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs

16.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>