These findings were made by Marion Bimmler, a graduate engineer of medical laboratory diagnostics at the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Dr. Peter Karczewski of the biotech company E.R.D.E.-AAK-Diagnostik GmbH in studies on a rat model.
Antibodies damage blood vessels in the brain of rats (see arrow in image B). Eight months after the rats were administered an antibody against a surface protein (alpha1-adrenergic receptor) in the vascular cells, the blood vessels are hardly recognizable, because the blood flow has been interrupted. Image A shows the blood vessels (white) in the brain of healthy animals with no antibodies. These findings are important for understanding the pathogenesis and progression of Alzheimer’s disease and vascular dementia.
(MR Angiography/Copyright: MDC)
Barbara Bachtler | Max-Delbrück-Centrum
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