The process, described in ACS' journal, Langmuir, can make other poorly soluble materials more soluble, and has potential for improving the performance of dyes, paints, rust-proofing agents and other products.
In the report, Yuri M. Lvov and colleagues point out that many drugs, including some of the most powerful anti-cancer medications, have low solubility in water, meaning they do not dissolve well. IV administration of large amounts can lead to clumping that blocks small blood vessels, so doses sometimes must be kept below the most effective level. In addition, drug companies may discontinue work on very promising potential new drugs that have low solubility. The scientists note numerous efforts to improve the solubility of such medications, none of which have been ideal.
The scientists describe using sonification, high-pitched sound waves like those in home ultrasonic jewelry and denture cleaners, to break anti-cancer drugs into particles so small that thousands would fit across the width of a human hair. Each particle of that power then gets several coatings with natural polysaccharides that keep them from sticking together. The technique, termed nanoencapsulation, worked with several widely used anti-cancer drugs, raising the possibility that it could be used to administer more-effective doses of the medications. The report also described successful use to increase the solubility of ingredients in rust proofing agents, paints, and dyes.
The authors acknowledge funding from the National Cancer Institute.
ARTICLE FOR IMMEDIATE RELEASE "Converting Poorly Soluble Materials into Stable Aqueous Nanocolloids"
DOWNLOAD FULL TEXT ARTICLE http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/la1041635
Michael Bernstein | EurekAlert!
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Second research flight into zero gravity
21.10.2016 | Universität Zürich
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences