George Kassiotis, from the Division of Immunoregulation at MRC National Institute for Medical Research, worked with a team of researchers to create mice whose CD4+ T cells, the cells eliminated by HIV infection, commit a kind of suicide upon activation.
He said, "Although these mice do not fully reproduce every aspect of human HIV-associated immune dysfunction, they do approximate two key immune alterations - CD4+ T cell immune deficiency and generalized immune activation. Further definition of the precise balance between CD4+ T cell killing and immune activation and deficiency will be vital to our understanding of the pathogenesis of immune deficiency virus infection."
The CD4+ T cells in the researchers' mice were engineered to express a toxin, diphtheria toxin A fragment, upon activation. This genetic self-destruct system causes the death of the cell within 48 hours. The resultant loss of activated immune cells caused the mice to exhibit symptoms with some similarities to those of immunodeficiency virus infection. There are clear differences between the mouse and a human infected with HIV, however, such as the fact that the ongoing depletion of nearly all activated CD4+ T cells in the mice does not result in the progressive erosion of naïve and memory CD4+ T cells seen during HIV infection. None-the-less, insights gained from this reductionist model can only help our understanding of human disease. In a commentary on the work in the same issue of Journal of Biology, experts on T cells and HIV at the US National Institutes of Health comment that the mouse will be as useful for its differences from human infection as it will for its similarities.
Notes to Editors:1. Generalized immune activation as a direct result of activated CD4+ T cell killing
Journal of Biology 2009, 8:93 doi:10.1186/jbiol194
2. Journal of Biology is an international journal that publishes biological research articles of exceptional interest or importance, together with associated commentary. Original research articles that are accepted for publication are published in full on the web within two weeks, and are immediately made freely available to all. Articles from the full spectrum of biology are appropriate for consideration, provided that they are of substantial interest or importance, or are likely to have a significant and lasting impact on their field.
3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy