Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A flash of light turns graphene into a biosensor

24.09.2009
Disease diagnosis, toxin detection and more are possible with DNA-graphene nanostructure

Biomedical researchers suspect graphene, a novel nanomaterial made of sheets of single carbon atoms, would be useful in a variety of applications. But no one had studied the interaction between graphene and DNA, the building block of all living things.

To learn more, PNNL's Zhiwen Tang, Yuehe Lin and colleagues from both PNNL and Princeton University built nanostructures of graphene and DNA. They attached a fluorescent molecule to the DNA to track the interaction. Tests showed that the fluorescence dimmed significantly when single-stranded DNA rested on graphene, but that double-stranded DNA only darkened slightly – an indication that single-stranded DNA had a stronger interaction with graphene than its double-stranded cousin.

The researchers then examined whether they could take advantage of the difference in fluorescence and binding. When they added complementary DNA to single-stranded DNA-graphene structures, they found the fluorescence glowed anew. This suggested the two DNAs intertwined and left the graphene surface as a new molecule.

DNA's ability to turns its fluorescent light switch on and off when near graphene could be used to create a biosensor, the researchers propose. Possible applications for a DNA-graphene biosensor include diagnosing diseases like cancer, detecting toxins in tainted food and detecting pathogens from biological weapons. Other tests also revealed that single-stranded DNA attached to graphene was less prone to being broken down by enzymes, which makes graphene-DNA structures especially stable. This could lead to drug delivery for gene therapy. Tang will discuss this research and some of its possible applications in medicine, food safety and biodefense.

Reference: Zhiwen Tang, Biofunctionalization of Graphene for Biosensing and Imaging, Tuesday, September 22, 3:30 – 5:30 p.m. in Ross Island/Morrison at the Doubletree Lloyd Center, Portland, Ore.

TIPSHEET: Scientists from the Department of Energy's Pacific Northwest National Laboratory will be presenting their research at the 2009 Micro Nano Breakthrough Conference, which runs Sept. 21-23 in Portland, Ore. http://oregonstate.edu/conferences/MNBC/.

This research was funded by PNNL as part of its Transformational Materials Science Initiative, http://materials.pnl.gov/.

Pacific Northwest National Laboratory is a Department of Energy Office of Science national laboratory where interdisciplinary teams advance science and technology and deliver solutions to America's most intractable problems in energy, national security and the environment. PNNL employs 4,200 staff and has an $850 million annual budget. Ohio-based Battelle has managed PNNL since the lab's inception in 1965.

Franny White | EurekAlert!
Further information:
http://www.pnl.gov

More articles from Life Sciences:

nachricht Hunting pathogens at full force
22.03.2017 | Helmholtz-Zentrum für Infektionsforschung

nachricht A 155 carat diamond with 92 mm diameter
22.03.2017 | Universität Augsburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Pulverizing electronic waste is green, clean -- and cold

22.03.2017 | Materials Sciences

Astronomers hazard a ride in a 'drifting carousel' to understand pulsating stars

22.03.2017 | Physics and Astronomy

New gel-like coating beefs up the performance of lithium-sulfur batteries

22.03.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>