Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Carbon nanotubes that detect disease-causing mutations developed by Pitt researcher

26.01.2006


Transistor channels can detect single DNA base mutations



University of Pittsburgh researcher Alexander Star and colleagues at California-based company Nanomix, Inc., have developed devices made of carbon nanotubes that can find mutations in genes causing hereditary diseases, they report in the Jan. 16 issue of the journal Proceedings of the National Academy of Science. This method is less expensive and takes less time than conventional techniques.

Carbon nanotubes are rolled-up sheets of graphite only a few nanometers wide-about the width of a molecule of DNA. The researchers used these nanotubes’ electrical properties to find a particular mutation in the gene that causes hereditary hemochromatosis, a disease in which too much iron accumulates in body tissues.


"The size compatibility between the detector and the detected species-DNA molecules in this case-makes this approach very attractive for further development of label-free electronic methods," said Star, who is an assistant professor of chemistry at Pitt.

Star and his colleagues at Nanomix also tested fluorescently labeled DNA molecules in order to confirm that DNA had attached to the nanotube surfaces and was subsequently hybridized, or matched to its complementary DNA.

"We have found that electrical measurement of carbon nanotube devices produce sensor results that are comparable to state-of-the-art optical techniques," Star said.

He added, "The applications of our method for detection of other, more serious genetic diseases can be seen."

Label-free electronic detection of DNA has several advantages over state-of-the-art optical techniques, including cost, time, and simplicity.

"Our technology can bring to market hand-held, field-ready devices for genetic screening, as opposed to laboratory methods using labor-intense labeling and sophisticated optical equipment," Star said.

This research was partially supported by the National Science Foundation’s Small Business Innovation Research program.

Karen Hoffmann | EurekAlert!
Further information:
http://www.pitt.edu
http://www.nano.pitt.edu

More articles from Interdisciplinary Research:

nachricht Fighting myocardial infarction with nanoparticle tandems
04.12.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Virtual Reality for Bacteria
01.12.2017 | Institute of Science and Technology Austria

All articles from Interdisciplinary Research >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>