VTT Technical Research Centre of Finland developed a new software tool megNet(r) for integration and visualization of complex life science and biomedical data. The new tool can be applied in understanding complex relations in living organisms, and characterizing various diseases, such as cardiac diseases and diabetes.
There has long been a pressing need to exploit efficiently research results in patient care. One of the key problems has been in linking clinically relevant information to the knowledge obtained across multiple disciplines, experimental platforms, and biological systems.
The megNet(r) enables integrative mining of, e.g., molecular interactions, genomes, gene expression profiles, metabolic profiles, medical images and clinical data. VTT is currently applying the megNet(r) to combine medical image and metabolomic data in search of new biomarkers for various diseases. The objective is also to link preclinical and clinical data in pharmaceutical development and healthcare with megNet(r)-tool.
VTT has applied in the development work of megNet(r) conceptual space theory for mining and visualizing life science and medical data. This includes state-of-the-art 3D techniques, mathematical modelling and contextualization. The theory of conceptual spaces combines elements from other theories in cognitive science, psychology and linguistics. It is based on the topological analysis of the information space that enables similarity to be modelled and computed in a natural way. It suits well for integration of complex clinical data such as medical images with molecular level information.
VTT has already applied the megNet(r) software tool in its research projects. In the VISUBIOMED project the researchers analyzed cardiac magnetic resonance images and in future other clinical data related to cardiac diseases. Metabolomics analyses can be performed from serum samples of the same patients. The data was complemented with molecular network information and with information on molecular interactions related to the disease. In the TRANSCENDO project VTT applied the megNet(r) in order to elucidate molecular pathways in the early stages of type 1 diabetes.
The work has been done in collaboration with hospitals.
VTT Technical Research Centre of Finland is the biggest contract research organization in Northern Europe. VTT provides high-end technology solutions and innovation services. From its wide knowledge base, VTT can combine different technologies, create new innovations and a substantial range of world-class technologies and applied research services, thus improving its clients' competitiveness and competence. Through its international scientific and technology network, VTT can produce information, upgrade technology knowledge and create business intelligence and value added to its stakeholders.
Stable magnetic bit of three atoms
21.09.2017 | Sonderforschungsbereich 668
Drones can almost see in the dark
20.09.2017 | Universität Zürich
At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.
Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
25.09.2017 | Physics and Astronomy
25.09.2017 | Trade Fair News
25.09.2017 | Physics and Astronomy