The results – which are published in the current issue of Nature Biotechnology – show that genes important for the development of diseases like Alzheimer’s follow the same cellular rules as genes involved in fundamentally different disorders, such as heart disorders, multiple sclerosis, breast cancer, and Type 2 diabetes.
”Many disorders manifest themselves in fundamentally different ways, but the new surprising discovery is that the underlying genes play together after the same rules. Our results show that the genes that trigger diseases, regardless of the type of disease in question, are social team players who cooperate according to highly specific rules. These rules have now been mapped, and we have pointed at hundreds of new genes that are likely to be involved in disorders including multiple sclerosis, Parkinson, heart disorders, and diabetes”, says Kasper Lage from Technical University of Denmark, who is the project coordinator on this work.
Heritable disorders will be easier to interpret for clinicians using the new results. Furthermore, the identification of new genes likely to be involved in disorders will help patients with defects in these genes. For example, if you are a high risk carrier of a gene that underlies a disease such as Type 2 diabetes, physicians could prevent or delay the manifestations of the disease by dietary guidance early in life.
”This is a crucial breakthrough for our understanding of heritable disorders, and a breakthrough for systems biology as a research strategy in the field genetics and disease”, says Søren Brunak leader of Center for Biological Sequence analysis at the Technical University of Denmark. ”We work with genes and proteins, but also with clinical literature describing the characteristics of different disorders. Then we let the computer integrate all of these data, and extract the pattern”, he adds.
The results are the product of a collaboration between the Center for Biological Sequence analysis, the Wilhelm Johannsen Center for Functional Genomics, Steno Diabetes Center in Denmark, and the SymBioSys Center for Computational Systems Biology, Katholieke Universiteit Leuven in Belgium.
A novel hybrid UAV that may change the way people operate drones
28.03.2017 | Science China Press
Timing a space laser with a NASA-style stopwatch
28.03.2017 | NASA/Goddard Space Flight Center
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Awards Funding
29.03.2017 | Health and Medicine
29.03.2017 | Earth Sciences