The issue coincides with the 2008 Alzheimer's Association International Conference on Alzheimer's Disease (ICAD), being held at McCormick Place, Chicago, July 26 to 31, 2008. Rudolph E. Tanzi, Ph.D., of the Massachusetts General Institute for Neurodegenerative Disease and Massachusetts General Hospital, is a Guest Editor. "In this issue of Neurotherapeutics, we have enlisted several experts in the field to review the most promising new therapeutics currently under development for the treatment and prevention of AD," Dr. Tanzi writes in the introductory editorial.
The eleven papers in the special issue highlight promising therapeutic targets for Alzheimer's disease, providing an update on efforts to develop treatments. Given the central role of amyloid ß peptide (Aß) in the pathogenesis of Alzheimer's disease, cerebral accumulations of Aß are a major focus. The lead article in the issue looks at techniques for measuring the effects of disease-modifying therapies on cerebral Aß levels—including the key question of whether they correlate with cognitive performance.
Clinical trials aimed at all of these therapeutic targets are underway. In his editorial, Dr. Tanzi expresses "cautious optimism and high hopes" that these trials may lead to new therapeutic approaches to Alzheimer's disease. He concludes, "With several active clinical trials and other promising drugs now headed toward the clinic, the hope is that we will soon have novel AD therapeutics that successfully slow or reverse disease progress in AD."
The full text of Dr. Bush's and Dr. Tanzi's paper on the metal hypothesis has been made available free of charge at http://www.neurotherapeutics.org/content/editorschoice. As always, subscribers and ASENT members can access the full content of each issue of Neurotherapeutics at the journal website, www.neurotherapeutics.org. Institutional subscribers can access the journal through ScienceDirect, http://www.ScienceDirect.com.
Visitors to ICAD 2008 in Chicago are encouraged to stop by the Elsevier display in the Expo Hall (Booth #710) to see the special issue on "Novel Therapeutics for Alzheimer's Disease" and to learn about options for becoming a Neurotherapeutics subscriber.
Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology
16.08.2017 | BIAS - Bremer Institut für angewandte Strahltechnik GmbH
Sustainability is the business model of tomorrow
04.08.2017 | Technische Universität Chemnitz
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
17.08.2017 | Physics and Astronomy
17.08.2017 | Earth Sciences
17.08.2017 | Physics and Astronomy