The U.S. Alzheimer's Association honors Dr. Eva-Maria Mandelkow and Prof. Dr. Eckhard Mandelkow from the German Center for Neurodegenerative Diseases (DZNE) and the caesar research center. The research couple receives the "2013 Khalid Iqbal Lifetime Achievement Award" for its role as pioneers in investigating the role of tau in Alzheimer's disease. The award ceremony was held yesterday (4: pm EST) within the framework of the "Alzheimer's Association International Conference (AAIC 2013)" in Boston (USA).
Since the 1990s, Eva-Maria and Eckhard Mandelkow have analyzed this protein. Longtime, the importance of the tau protein in Alzheimer’s disease has been underestimated. “At that time, no one would have thought that tau has such a significant role. However, we have pursued this approach because we have been interested in the role of Tau in nerve cells“ said Eva-Maria Mandelkow.
In pioneering studies, she and her husband have shown why the tau protein lumps in the brain and which sections of the molecular structure are thereby decisive. These findings allowed the couple to examine the consequences of the aggregation of the tau protein for the nerve cells in more detail. The result: Modifications of normal tau destroy the synapses of nerve cells. This is for example shown by studies on mice. If the protein accumulates in nerve cells, these mice perform worse in learning and memory tests than healthy animals and develop typical symptoms of Alzheimer's disease. In the event that the production of the toxic tau in the cells is stopped, the synapses regenerate and the mice recover from amnesia. This observation shows that the disease process is in principle reversible.
Eckhard Mandelkow: "I am of the opinion that an effective therapy against Alzheimer is possible. Crucial, in my view, is that the treatment is started early enough. Many of today's therapy approaches might have failed on account of the fact that they are applied too late. Since a disease is usually only diagnosed when typical symptoms such as memory dysfunctions are evident. At this time, the brain is however already severely damaged."
Recently, the couple has examined 200,000 substances, in order to find an active agent against the aggregation of tau. Some of these substances were found to be potential candidates for drugs. Their effect will now be further explored.
Prof. Dr. Eckhard Mandelkow studied physics and did his PhD at the Max Planck Institute for Medical Research in Heidelberg on the structure of virus proteins. In a subsequent research period at the Brandeis University (USA), he already dealt with proteins of the cytoskeleton and then continued this line of research. Then he focused on the structure and function of proteins of the nerve cells, especially of motor proteins, tau proteins and their pathological changes during the neurodegeneration. He is the head of the working group "Structural principles of neurodegeneration" at the DZNE/caesar in Bonn.
Dr. Eva-Maria Mandelkow studied medicine, worked for several years in the clinic and then pursued a career in fundamental research. She received her PhD at the Max Planck Institute for Medical Research in Heidelberg for her work in muscle physiology. This was followed by research periods at the Brandeis University (USA), the Scripps Research Institute (USA) and at the MRC Laboratory in Cambridge (UK), where she dealt with proteins of the cytoskeleton. Eva-Maria Mandelkow heads the working group "Cell and animal models of neurodegeneration" at the DZNE/caesar in Bonn.
ContactDr. Eva-Maria und Prof. Dr. Eckhard Mandelkow DZNE, Bonn and caesar research center
Sonja Jülich-Abbas | idw
The quest for the oldest ice on Earth
14.11.2016 | Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung
Empa Innovation Award for new flame retardant
09.11.2016 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine