Scientists from the John Innes Centre have proven that by taking a short stretch of DNA from a bacterium and delivering it with an existing antibiotic they can switch off antibiotic resistance.
Together with technology transfer company PBL, the scientists have launched a spin-out company, Procarta Biosystems Ltd, to develop the technology.
“The DNA sequence acts as a decoy, disrupting gene expression and blocking resistance”, said Dr Michael McArthur from JIC.
“We are putting genetic information directly into drugs. This is the first application of a DNA based therapy”.
The scientists have also patented a way of discovering decoys in bacteria without necessarily having to know the genes involved. This means they can develop effective new drugs against any bacterium within a couple of years and at a fraction of the normal cost.
The technology can give fresh patent life to existing antibiotics - when combined with a decoy they can be patented as a new drug.
This comes at a time when the number of new antibiotics receiving approval has dramatically declined. Faced with antibiotic resistance the pharmaceutical industry is unlikely to be able to deliver new products.
“Natural resistance will always be hot on the heels of a new antibiotic because they co-evolve”, said Dr McArthur. “Ours’ is not a traditional pharmaceutical approach and provides a completely new challenge to bacteria”.
The technology can also be used to improve the production of antibiotics by bacteria and to produce enzymes and other compounds using bacteria for use in industrial processes.
Many industrial processes are harsh and unsustainable, using petrochemicals, high temperatures and creating toxic by-products. In industrial biotechnology, also called “white biotechnology”, bacteria make medically and commercially important compounds biologically.
“By using bacteria, many industrial processes could be cleaned up”, said Dr McArthur.
The Procarta scientists found that the bacterium Streptomyces produces a particularly high yield of enzymes and proteins. Unusually, it can also secrete the proteins it produces so they do not have to be extracted.
“Streptomyces is the enzyme producing bacterium with bells and whistles, set to make a major contribution to a market already predicted to be worth £400 million by 2010”, said Dr McArthur.
We use the products of white biotechnology in our everyday lives. They contribute to ingredients in the food we eat, energy we use that has been generated with renewable biomass rather than fossil fuels, medicines we take, and everyday products such as detergents, paint and paper.
Zoe Dunford | alfa
Researchers discover a new link to fight billion-dollar threat to soybean production
14.02.2017 | University of Missouri-Columbia
Important to maintain a diversity of habitats in the sea
14.02.2017 | University of Gothenburg
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
22.02.2017 | Power and Electrical Engineering
22.02.2017 | Life Sciences
22.02.2017 | Physics and Astronomy