Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An improved vaccine against paratuberculosis?

25.05.2007
Paratuberculosis is a disease resembling tuberculosis, which in Norway primarily affects goats. Research carried out by Ólöf G. Sigurðardóttir of the National Veterinary Institute may contribute to the development of a new and better vaccine.

For her Dr .med. vet. degree at the Norwegian School of Veterinary Science, Ólöf G. Sigurðardóttir studied and described early inflammatory changes in the intestines of goats with paratuberculosis, in order to better understand the development of the disease. She also investigated the routes of infection of paratuberculosis in the intestine.

Paratuberculosis is caused by the bacterium Mycobacterium avium subsp. paratuberculosis, which is related to the tuberculosis bacterium. While tuberculosis in man causes pneumonia, paratuberculosis produces inflammation in the intestine in ruminants. In Norway, paratuberculosis is primarily a disease of goats. After infection, inflammation develops in the intestine and slowly progresses, gradually leading to wasting, reduced yield, and eventually death.

Our present vaccines keep the frequency of the disease at a low level, but do not protect goats against infection with the paratuberculosis agent. Newer vaccines can provide improved protection against the disease if they can stimulate the local defensive mechanisms that exists in the intestine, and especially if they utilise the same pathways of infiltration as does the bacterium.

“My studies have shown that the paratuberculosis bacterium invades the intestine through specialised cells in the mucous membrane of the intestine. These cells are located in regions of the intestine that are important for the immunological surveillance of the intestinal tract. Inflammation with paratuberculosis develops in these regions and gradually spreads throughout the intestine.

If future vaccines are absorbed through these same specialised cells, they will be able to initiate local, effective means of defence in the intestine and will therefore be able to protect ruminants against paratuberculosis”, says Ólöf G. Sigurðardóttir.

On April 22, 2007, Ólöf G. Sigurðardóttir defended her thesis for the degree of Doctor Medicinae Veterinariae, entitled “Paratuberculosis in goats – a study of the uptake of Mycobacterium avium subsp. paratuberculosis and pathology of early subclinical infection”.

Magnhild Jenssen | alfa
Further information:
http://www.veths.no
http://www.veths.no/templates/Page.aspx?id=8953

More articles from Agricultural and Forestry Science:

nachricht Energy crop production on conservation lands may not boost greenhouse gases
13.03.2017 | Penn State

nachricht How nature creates forest diversity
07.03.2017 | International Institute for Applied Systems Analysis (IIASA)

All articles from Agricultural and Forestry Science >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>