Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An improved vaccine against paratuberculosis?

25.05.2007
Paratuberculosis is a disease resembling tuberculosis, which in Norway primarily affects goats. Research carried out by Ólöf G. Sigurðardóttir of the National Veterinary Institute may contribute to the development of a new and better vaccine.

For her Dr .med. vet. degree at the Norwegian School of Veterinary Science, Ólöf G. Sigurðardóttir studied and described early inflammatory changes in the intestines of goats with paratuberculosis, in order to better understand the development of the disease. She also investigated the routes of infection of paratuberculosis in the intestine.

Paratuberculosis is caused by the bacterium Mycobacterium avium subsp. paratuberculosis, which is related to the tuberculosis bacterium. While tuberculosis in man causes pneumonia, paratuberculosis produces inflammation in the intestine in ruminants. In Norway, paratuberculosis is primarily a disease of goats. After infection, inflammation develops in the intestine and slowly progresses, gradually leading to wasting, reduced yield, and eventually death.

Our present vaccines keep the frequency of the disease at a low level, but do not protect goats against infection with the paratuberculosis agent. Newer vaccines can provide improved protection against the disease if they can stimulate the local defensive mechanisms that exists in the intestine, and especially if they utilise the same pathways of infiltration as does the bacterium.

“My studies have shown that the paratuberculosis bacterium invades the intestine through specialised cells in the mucous membrane of the intestine. These cells are located in regions of the intestine that are important for the immunological surveillance of the intestinal tract. Inflammation with paratuberculosis develops in these regions and gradually spreads throughout the intestine.

If future vaccines are absorbed through these same specialised cells, they will be able to initiate local, effective means of defence in the intestine and will therefore be able to protect ruminants against paratuberculosis”, says Ólöf G. Sigurðardóttir.

On April 22, 2007, Ólöf G. Sigurðardóttir defended her thesis for the degree of Doctor Medicinae Veterinariae, entitled “Paratuberculosis in goats – a study of the uptake of Mycobacterium avium subsp. paratuberculosis and pathology of early subclinical infection”.

Magnhild Jenssen | alfa
Further information:
http://www.veths.no
http://www.veths.no/templates/Page.aspx?id=8953

More articles from Agricultural and Forestry Science:

nachricht Climate change, population growth may lead to open ocean aquaculture
05.10.2017 | Oregon State University

nachricht New machine evaluates soybean at harvest for quality
04.10.2017 | University of Illinois College of Agricultural, Consumer and Environmental Sciences

All articles from Agricultural and Forestry Science >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>