Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An improved vaccine against paratuberculosis?

25.05.2007
Paratuberculosis is a disease resembling tuberculosis, which in Norway primarily affects goats. Research carried out by Ólöf G. Sigurðardóttir of the National Veterinary Institute may contribute to the development of a new and better vaccine.

For her Dr .med. vet. degree at the Norwegian School of Veterinary Science, Ólöf G. Sigurðardóttir studied and described early inflammatory changes in the intestines of goats with paratuberculosis, in order to better understand the development of the disease. She also investigated the routes of infection of paratuberculosis in the intestine.

Paratuberculosis is caused by the bacterium Mycobacterium avium subsp. paratuberculosis, which is related to the tuberculosis bacterium. While tuberculosis in man causes pneumonia, paratuberculosis produces inflammation in the intestine in ruminants. In Norway, paratuberculosis is primarily a disease of goats. After infection, inflammation develops in the intestine and slowly progresses, gradually leading to wasting, reduced yield, and eventually death.

Our present vaccines keep the frequency of the disease at a low level, but do not protect goats against infection with the paratuberculosis agent. Newer vaccines can provide improved protection against the disease if they can stimulate the local defensive mechanisms that exists in the intestine, and especially if they utilise the same pathways of infiltration as does the bacterium.

“My studies have shown that the paratuberculosis bacterium invades the intestine through specialised cells in the mucous membrane of the intestine. These cells are located in regions of the intestine that are important for the immunological surveillance of the intestinal tract. Inflammation with paratuberculosis develops in these regions and gradually spreads throughout the intestine.

If future vaccines are absorbed through these same specialised cells, they will be able to initiate local, effective means of defence in the intestine and will therefore be able to protect ruminants against paratuberculosis”, says Ólöf G. Sigurðardóttir.

On April 22, 2007, Ólöf G. Sigurðardóttir defended her thesis for the degree of Doctor Medicinae Veterinariae, entitled “Paratuberculosis in goats – a study of the uptake of Mycobacterium avium subsp. paratuberculosis and pathology of early subclinical infection”.

Magnhild Jenssen | alfa
Further information:
http://www.veths.no
http://www.veths.no/templates/Page.aspx?id=8953

More articles from Agricultural and Forestry Science:

nachricht Faba fix for corn's nitrogen need
11.04.2018 | American Society of Agronomy

nachricht Wheat research discovery yields genetic secrets that could shape future crops
09.04.2018 | John Innes Centre

All articles from Agricultural and Forestry Science >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

World's smallest optical implantable biodevice

26.04.2018 | Power and Electrical Engineering

Molecular evolution: How the building blocks of life may form in space

26.04.2018 | Life Sciences

First Li-Fi-product with technology from Fraunhofer HHI launched in Japan

26.04.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>