Chemokine-capturing wound contact layer rescues dermal healing

Scheme/frontispiece
by permission of Wiley VCH GmbH

Publication in Advanced Science…

Experts estimate that between two and four million people in Germany suffer from chronic skin wounds that are difficult to treat. Researchers at the Leibniz Institute of Polymer Research Dresden e.V. for the first time developed and tested a wound dressing that reduces the increased inflammation in chronic wounds and thus supports healing.

Anti-inflammatory hydrogels containing glycosaminoglycans, a class of naturally occurring carbohydrates, were combined with textile carriers to create an easily applicable and clinically useful form of the technology.

As part of Transregional Collaborative Research Center 67, “Functional Biomaterials to Control Healing Processes in Bone and Skin Tissue,” funded by the German Research Foundation, the interdisciplinary team of researchers explored a new approach to neutralize pro-inflammatory chemokines on chronic wounds in a large animal (pig) model of diabetes.

By targeting biomolecular interactions, pro-inflammatory chemokines were effectively bound in the wound dressing and thus inactivated. As reported in the current issue of Advanced Science, treatment with the innovative wound dressing enabled healing of chronic skin wounds in the aforementioned animal model.

Clinical translation of the promising technology could create new treatment options for patients with wound healing disorders. Currently, plans are underway to conduct a clinical trial and to establish a spin-off company.

Wissenschaftliche Ansprechpartner:

Prof. Dr. Carsten Werner, werner@ipfdd.de, Phone: +49 351 4658 531

Originalpublikation:

Schirmer, L., Atallah, P., Freudenberg, U., Werner, C., Chemokine-Capturing Wound Contact Layer Rescues Dermal Healing. Adv. Sci. 2021, 8, 2100293.
https://onlinelibrary.wiley.com/doi/10.1002/advs.202100293

http://www.ipfdd.de

Media Contact

Kerstin Wustrack Öffentlichkeitsarbeit
Leibniz-Institut für Polymerforschung Dresden e. V.

All latest news from the category: Life Sciences and Chemistry

Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to home

Comments (0)

Write a comment

Newest articles

Finding the ship that sent out a warning to The Titanic

New powerful technology reveals lost seabed structures. The ship which sent an iceberg warning to the RMS Titanic, before the ocean-liner sank, has been identified lying in the Irish Sea….

Quantum technology reaches unprecedented control over captured light

Researchers in quantum technology at Chalmers University of Technology have succeeded in developing a technique to control quantum states of light in a three-dimensional cavity. In addition to creating previously…

Tiny swimming robots treat deadly pneumonia in mice

Nanoengineers at the University of California San Diego have developed microscopic robots, called microrobots, that can swim around in the lungs, deliver medication and be used to clear up life-threatening…

Partners & Sponsors