Chemokine-capturing wound contact layer rescues dermal healing
Scheme/frontispiece
by permission of Wiley VCH GmbH
Publication in Advanced Science…
Experts estimate that between two and four million people in Germany suffer from chronic skin wounds that are difficult to treat. Researchers at the Leibniz Institute of Polymer Research Dresden e.V. for the first time developed and tested a wound dressing that reduces the increased inflammation in chronic wounds and thus supports healing.
Anti-inflammatory hydrogels containing glycosaminoglycans, a class of naturally occurring carbohydrates, were combined with textile carriers to create an easily applicable and clinically useful form of the technology.
As part of Transregional Collaborative Research Center 67, “Functional Biomaterials to Control Healing Processes in Bone and Skin Tissue,” funded by the German Research Foundation, the interdisciplinary team of researchers explored a new approach to neutralize pro-inflammatory chemokines on chronic wounds in a large animal (pig) model of diabetes.
By targeting biomolecular interactions, pro-inflammatory chemokines were effectively bound in the wound dressing and thus inactivated. As reported in the current issue of Advanced Science, treatment with the innovative wound dressing enabled healing of chronic skin wounds in the aforementioned animal model.
Clinical translation of the promising technology could create new treatment options for patients with wound healing disorders. Currently, plans are underway to conduct a clinical trial and to establish a spin-off company.
Wissenschaftliche Ansprechpartner:
Prof. Dr. Carsten Werner, werner@ipfdd.de, Phone: +49 351 4658 531
Originalpublikation:
Schirmer, L., Atallah, P., Freudenberg, U., Werner, C., Chemokine-Capturing Wound Contact Layer Rescues Dermal Healing. Adv. Sci. 2021, 8, 2100293.
https://onlinelibrary.wiley.com/doi/10.1002/advs.202100293
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