Physicists are getting more involved in the fight against diseases by studying the folding of proteins, which they hope will eventually lead to the development of new drugs. Illnesses such as Alzheimers disease and even some cancers are the result of protein folding that has gone awry. Since proteins in the body perform different functions according to their shape, the folding process is considered a very important area of study.
Everett Lipman, a new assistant professor of physics at the University of California, Santa Barbara, recently co-authored an article in the journal Science, describing an innovative study of how to "see" proteins as they fold, the result of experiments performed with co-workers at the National Institutes of Health.
The machinery of life arises from interactions between protein molecules, whose functions depend on the three-dimensional shapes into which they fold, said Lipman. Although proteins are composed of just 20 different building blocks (the amino acids), the process by which a given sequence of these components adopts its unique structure is complex and poorly understood. Folding proteins are too small to view with a microscope, so the researchers used a method called Forster Resonance Energy Transfer, or FRET, to study them. Using a microfabricated silicon device and a microfluidic mixing technique, they were able to observe single protein molecules at various times after folding was triggered.
Gail Gallessich | EurekAlert!
Unraveling the nature of 'whistlers' from space in the lab
15.08.2018 | American Institute of Physics
Early opaque universe linked to galaxy scarcity
15.08.2018 | University of California - Riverside
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
16.08.2018 | Information Technology
16.08.2018 | Health and Medicine
16.08.2018 | Information Technology