Can skin cancer be treated with light? Scientists at the University of California, Irvine (UC Irvine), believe so.
They're exploring new ways to image cancerous lesions using LEDs that might advance a technique for treating cancer called photodynamic therapy (PDT) -- work that they will describe at the Optical Society's (OSA) 94th annual meeting, Frontiers in Optics (FiO) 2010 at the Rochester Riverside Convention Center in Rochester, N.Y., from Oct. 24-28.
In PDT, photosensitizing chemicals that absorb light are injected into a tumor, which is then exposed to light. The chemicals generate oxygen radicals from the light energy, destroying the cancer cells. PDT is currently approved by the U.S. Food and Drug Administration (FDA) for the treatment of esophageal and lung cancer.
Rolf Saager, who works in the lab of Anthony Durkin at the Beckman Laser Institute at UC Irvine in collaboration with Kristen Kelly, M.D., and Modulated Imaging Inc., believes that PDT could also be used to treat skin cancer. But one obstacle to this application is the lack of a detailed imaging technique to target and monitor the effectiveness of PDT.
Exploiting a technique known as spatial frequency domain imaging, the team has designed a new device with an array of five different colors of LEDs that illuminates skin with distinct intensity patterns. These patterns can change depending on the structure of the tissue and the pigments in the skin. With appropriate models of light propagation, the resulting images reveal the biochemistry of the tissue.
"Through this imaging modality, it is now possible to assess how the therapeutic light will travel throughout the affected tissue, quantify the drug present within the lesion and monitor its efficacy during treatment," says Saager.
To evaluate this spatial frequency domain imaging system, the scientists imaged a small population of skin cancers prior to treatment to characterize the variability among subjects and within the lesions themselves. The process took 5-10 seconds and produced images with a resolution of 30 microns, revealing spatially resolved maps of the optical properties of the lesions, tissue oxygenation and quantitative distribution of the photosensitizing drug.
Saager and colleagues hope that this imaging technique will provide a better map for targeting and optimizing photodynamic therapy for basal cell carcinoma, the most common type of skin cancer. The next step for their ongoing experiment will be to enable the therapeutic aspects of the instrument and monitor the tissue dynamics during PDT treatment regimens.
The talk, "A LED Based Spatial Frequency Domain Imaging System for Optimization of Photodynamic Therapy of Basal Cell Carcinoma (BCC)" is at 2 p.m. Tuesday, Oct. 26.
About the Meeting
Frontiers in Optics 2010 is OSA's 94th Annual Meeting and is being held together with Laser Science XXVI, the annual meeting of the American Physical Society (APS) Division of Laser Science (DLS). The two meetings unite the OSA and APS communities for five days of quality, cutting-edge presentations, fascinating invited speakers and a variety of special events spanning a broad range of topics in physics, biology and chemistry. FiO 2010 will also offer a number of Short Courses designed to increase participants' knowledge of a specific subject while offering the experience of insightful teachers. An exhibit floor featuring leading optics companies will further enhance the meeting.
Useful Links:Meeting home page
EDITOR'S NOTE: A Press Room for credentialed press and analysts will be located in Aqueduct AB of the Rochester Riverside Convention Center, Sunday through Thursday. Those interested in obtaining a press badge for FiO should contact OSA's Lyndsay Basista at +1 202.416.1930 or email@example.com.
Uniting more than 106,000 professionals from 134 countries, the Optical Society (OSA) brings together the global optics community through its programs and initiatives. Since 1916 OSA has worked to advance the common interests of the field, providing educational resources to the scientists, engineers and business leaders who work in the field by promoting the science of light and the advanced technologies made possible by optics and photonics. OSA publications, events, technical groups and programs foster optics knowledge and scientific collaboration among all those with an interest in optics and photonics. For more information, visit www.osa.org.
Lyndsay Basista | EurekAlert!
Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)
Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences