Oak Crest scientists develop novel subdermal implant for the prevention and treatment of HIV/AIDS
Is the end of HIV near? Findings published this week in Antimicrobial Agents and Chemotherapy report that a novel, subdermal implant delivering potent antiretroviral (ARV) drugs shows extreme promise in stopping the spread of HIV.
The novel, subdermal implant, developed by scientists from the Oak Crest Institute of Science, provides sustained release of potent antiretroviral drugs which are showing extreme promise in preventing sexually transmitted HIV when used as pre-exposure prophylaxis.
Photos by Gunawardana, M and Remedios-Chan, M.
Scientists from the Oak Crest Institute of Science, in Pasadena, CA, report that they have developed a matchstick size implant, similar to a contraceptive implant, that successfully delivers a controlled, sustained release of ARV drugs for up to 40 days in dogs with no adverse side effects.
"To our knowledge this is the first implant to be used for this purpose," says Dr. Marc Baum, president and founder of Oak Crest.
Daily administration of oral or topical ARV drugs to HIV negative individuals in vulnerable populations is a promising strategy for HIV prevention. However, adherence to the dosing regimen has emerged as a critical factor in determining effective outcomes in clinical trials.
"This novel device will revolutionize how we treat or prevent HIV/AIDS as it delivers powerful HIV-stopping drugs and eliminates one of the key obstacles in HIV/AIDS prevention - adherence to proper dosing regimens," he adds.
Medical practitioners and scientists acknowledge that one of the main drawbacks in current medical treatments is the problem of adherence. "It's unfortunate, but patients do not always follow the dosing instructions as prescribed," says Dr. Baum. "In clinical trials erratic administration of drugs has led to highly variable efficacy outcomes. That's what peaked our interest in the possible use of a subdermal implant for the prevention of HIV," suggests Dr. Baum.
The use of subdermal implants for contraception began in the United States in 1993. The small flexible tube, measuring about 40mm in length, is inserted under the skin by a health care professional (typically the upper arm). After it is inserted it prevents pregnancy by releasing hormones that prevent ovaries from releasing eggs and by thickening cervical mucous.
"Our subdermal implant is used in the same manner as a contraceptive implant. It is easily inserted and removed and provides sustained release of the potent prodrug tenofovir alafenamide, which is roughly ten times more potent against HIV than tenofovir disoproxil fumarate, another tenofovir prodrug that has been shown to prevent sexually transmitted HIV when used as a pre-exposure prophylaxis," adds Dr. Baum.
"We are very pleased with the results of our preliminary studies and are working diligently to develop a subdermal implant for HIV prevention that will remain effective for a full 12 months."
Dr. Marc Baum | EurekAlert!
The genes are not to blame
20.07.2018 | Technische Universität München
Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences