A team including researchers at the Total Defense Research Institute, NBC Defense, in Umeå, Sweden, and the Department of Molecular Biology, Umeå University, are publishing in this week’s issue of Science new findings that show that the protein Ymt is of crucial importance for the capacity of the plague bacterium to survive and spread the plague via flea vectors. Professor Åke Forsberg and visiting researcher Dr. Peter Cherepanov are studying the properties that enable the plague bacterium Yersinia pestis to cause life-threatening infections in animals and humans. Increased knowledge of the mechanisms that Y. pestis exploits to conquer the body’s immune defense can make it possible to develop new methods of treatment for serious infectious diseases.
Historically, the plague is one of our most feared infectious diseases. During the most wide-spread epidemic in the middle ages, also known as the Black Death, more than 25% of the European population died. Today the disease is not very common, with some 2,000 cases per year. The plague occurs primarily in Africa and Asia, but there are also a few cases in North America every year.
The bacteria are normally spread by fleas, first of all to rodents. Humans can also be infected by fleas. When the disease reaches the lungs of a human, the infection can be spread through the air to other people. The onset of the disease is rapid, with a high temperature and a headache. There is often an enlargement of the lymph glands located near the back of the jaw, which explains why it is also called the bubonic plague. Untreated, the infection quickly reaches the blood, leading to general blood poisoning. Mortality for untreated bubonic plague is over 50%. If the infection is spread by the air to the lungs, the course of the disease is even more rapid, and mortality for untreated lung plague is virtually 100%. The high rate of mortality, together with the rapid progression of the disease, places plague bacteria among those considered for use as a biological weapon.
Ulrika Bergfors Kriström | alphagalileo
Researchers find trigger that turns strep infections into flesh-eating disease
19.02.2019 | Houston Methodist
Loss of identity in immune cells explained
18.02.2019 | Technische Universität München
Up to now, OLEDs have been used exclusively as a novel lighting technology for use in luminaires and lamps. However, flexible organic technology can offer much more: as an active lighting surface, it can be combined with a wide variety of materials, not just to modify but to revolutionize the functionality and design of countless existing products. To exemplify this, the Fraunhofer FEP together with the company EMDE development of light GmbH will be presenting hybrid flexible OLEDs integrated into textile designs within the EU-funded project PI-SCALE for the first time at LOPEC (March 19-21, 2019 in Munich, Germany) as examples of some of the many possible applications.
The Fraunhofer FEP, a provider of research and development services in the field of organic electronics, has long been involved in the development of...
For the first time, an international team of scientists based in Regensburg, Germany, has recorded the orbitals of single molecules in different charge states in a novel type of microscopy. The research findings are published under the title “Mapping orbital changes upon electron transfer with tunneling microscopy on insulators” in the prestigious journal “Nature”.
The building blocks of matter surrounding us are atoms and molecules. The properties of that matter, however, are often not set by these building blocks...
Scientists at the University of Konstanz identify fierce competition between the human immune system and bacterial pathogens
Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the...
Laser physicists have taken snapshots of carbon molecules C₆₀ showing how they transform in intense infrared light
When carbon molecules C₆₀ are exposed to an intense infrared light, they change their ball-like structure to a more elongated version. This has now been...
The so-called Abelian sandpile model has been studied by scientists for more than 30 years to better understand a physical phenomenon called self-organized...
11.02.2019 | Event News
30.01.2019 | Event News
16.01.2019 | Event News
20.02.2019 | Life Sciences
20.02.2019 | Medical Engineering
20.02.2019 | Power and Electrical Engineering