A University of Calgary, Canada team led by Dr. Robert Myers used administrative data to review over 1500 patients hospitalised for acetaminophen overdose between 1995 and 2004. Since 1995, the hospitalisation rate has dropped 41% from 19.6 per 100 000 population to 12.1 per 100 000 in 2004. Myers’ team found that although for under 50s the rate fell 46%, there was a 50% jump in hospitalisations for the over 50s. Female overdosing fell to a greater extent than it did for males (46% vs. 29%).
The majority of overdoses were intentional (85%), with the remainder made up of 13% accidental cases and 2% homicides or of unclear intent. Accidental overdoses fell between 1995 and 2002, but then began to rise again. Over 100 products are available over the counter, sometimes containing relatively large amounts of acetaminophen. The authors suggest that lack of patient and physician awareness may account for at least part of the increase in accidental overdoses.
In 1998 UK legislation limited packets of acetaminophen to 16 x 500mg tablets. The authors note the overdose rate in Calgary is about one fifth that reported in the UK, despite similar suicide rates. UK acetaminophen overdose cuts have largely been attributed to the package size restrictions, however no such restrictions have been imposed in Canada. Acetaminophen (paracetamol) overdose is the most common cause of acute liver failure, accounting for as many as 50% of acute liver failure cases.
Charlotte Webber | alfa
New flexible, transparent, wearable biopatch, improves cellular observation, drug delivery
12.11.2018 | Purdue University
Exosomes 'swarm' to protect against bacteria inhaled through the nose
12.11.2018 | Massachusetts Eye and Ear Infirmary
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
Scientists developed specially coated nanometer-sized vehicles that can be actively moved through dense tissue like the vitreous of the eye. So far, the transport of nano-vehicles has only been demonstrated in model systems or biological fluids, but not in real tissue. The work was published in the journal Science Advances and constitutes one step further towards nanorobots becoming minimally-invasive tools for precisely delivering medicine to where it is needed.
Researchers of the “Micro, Nano and Molecular Systems” Lab at the Max Planck Institute for Intelligent Systems in Stuttgart, together with an international...
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