Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Over 1/3 of refractory lupus patients remain stable at long term follow-up after receiving B-cell depletion therapy

15.06.2007
Findings reported today at EULAR 2007, the Annual European Congress of Rheumatology (EULAR) in Barcelona, Spain, reveal a treatment disparity between female and male patients with rheumatoid arthritis (RA). Data from a study at the Karolinska Institute, Sweden, show that women receive anti-TNFs (very effective but expensive modern medications against this disease) at a higher perceived level of disease activity and when they are reporting more severe pain than their male counterparts.

Whilst some disease activity measurements were found to be higher for women than men, and self-reported disease activity by the patients themselves echoed this, the physicians’ global assessments showed little difference between the level of disease in the men and women of the study group.

Lead researcher Dr Ronald van Vollenhoven comments, “Women are known to have consistently worse long-term outcomes in rheumatoid arthritis than men. To date, it has been unclear if this is due to factors intrinsic to the disease or because of gender-related prescribing. Our study does not show a gender-bias as such, but does indicate that physicians to some extent ‘discount’ the subjective measures of disease activity, which we found to be higher in women, and let their decisions be driven almost solely by objective markers of the disease. As a result, women are receiving anti-TNFs at a higher level of disease symptoms than men. Because the goal of any treatment for RA must be to relieve the patients suffering, it is not clear that this approach is the right one.”

The study analysed baseline variables for the patients on RA who were started on anti-TNF treatment in the STURE Registry (the Stockholm TNF-alpha follow-up registry). When anti-TNFs were first prescribed to the 644 study participants, the level of their RA severity was logged, as measured according to Disease Activity Scale 28 (DAS28) which takes into account the severity of disease across the 28 joints most commonly affected by RA.

Each participant’s Erythrocyte Sedimentation Rate (ESR), which measures the level of inflammation, was also noted along with their Swollen Joint Count (SJC) and Tender Joint Count (TJC). Furthermore, both patients and their physicians completed a global assessment of disease activity, pain and physical activity (5 point scale questionnaire).

DAS28 scores at initiation of anti-TNF treatment were found to be significantly higher for women than for men (DAS28 was 5.53 for women, 5.04 for men, p=0.0006) and women had higher Tender Joint Counts (9.62 compared to 8.41 for males, p=0.066). The women in the study also had significantly higher ESR scores, although the authors suggest that this could be explained in part by the female hormone oestrogen, which affects tends to raise the ESR.

With regard to the more subjective self-reporting on the disease, through the patient-completed global health ratings, women also reported significantly worse global health (as measured by VAS and HAQ-disability index). However, the physician-completed global health ratings were equivalent for men and women.

Dr Ronald van Vollenhoven comments, “This study shows the importance of taking into account both objective and subjective measurement scores in treatment decisions. It is our hope that these data will help redress this imbalance and ensure equal prescribing and disease management for all.”

Rory Berrie | alfa
Further information:
http://www.eular.org

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

A paper battery powered by bacteria

21.08.2018 | Power and Electrical Engineering

Protein interaction helps Yersinia cause disease

21.08.2018 | Life Sciences

Biosensor allows real-time oxygen monitoring for 'organs-on-a-chip'

21.08.2018 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>