Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antioxidant protects against lung damage in silicosis

17.10.2006
Levels of heme oxygenase-1 (HO-1), an antioxidant that protects against reactive oxygen species (damaging oxygen molecules that cause direct tissue injury), become elevated in the lungs of chronic silicosis patients and could represent a new treatment approach for the disease.

These results appear in the second issue for October 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Yoshiaki Ishigatsubo, M.D., Ph.D., of the Department of Internal Medicine and Clinical Immunology at Yokohama City University in Japan, and 11 associates studied 46 male patients with silicosis, an inflammatory disorder caused by inhaling crystalline silica for prolonged periods. The study included 27 male patients with chronic obstructive pulmonary disease and 27 healthy male volunteers as controls. The investigators also studied a mouse model of silicosis.

Silicosis results from exposure to crystalline silica in mines and foundries, at sand blasting operations and at stone, clay, and glass manufacturing plants. Crystalline silica induces the production of reactive oxygen species, which can cause scar tissue to develop in the lungs.

About 1 million workers are believed to have been exposed to silica dust in the U.S. More than 10,000 silicosis patients are currently being followed in Japan.

"Pulmonary HO-1 expression is increased in silicosis," said Dr. Ishigatsubo. "HO-1 suppresses reactive oxygen species activity, and its subsequent pathologic changes, thereby reducing disease progression."

The researchers noted that their work was the first to demonstrate that HO-1 is synthesized in the lungs of patients with silicosis, thus contributing to a significant elevation of serum HO-1 levels in these patients.

"Silica particles were consistently associated with lesions containing HO-1 expressing cells," added Dr. Ishigatsubo. "The number of HO-1-expressing cells was significantly higher in patients with silicosis than in control subjects."

The investigators said that their present results indicate that silicosis patients' serum HO-1 levels correlate significantly with their primary lung function test level and vital capacity. (Vital capacity is the maximum amount of air that can be exhaled after a maximum inhalation, showing the status of lung tissue.)

The authors believe that if serum HO-1 derives primarily from lung lesions, it could also represent a novel biomarker for evaluating the severity of silicosis.

In their mouse studies, hemin, a potent inducer of HO-1, suppressed acute inflammation after silica exposure, whereas zinc protoporphyrin, an inhibitor of HO-1, accelerated the development of silicosis lesions.

Suzy Martin | EurekAlert!
Further information:
http://www.thoracic.org

More articles from Health and Medicine:

nachricht New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute

nachricht Distrust of power influences choice of medical procedures
01.08.2018 | Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

Im Focus: World record: Fastest 3-D tomographic images at BESSY II

The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.

Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

First study on physical properties of giant cancer cells may inform new treatments

14.08.2018 | Life Sciences

Tiny Helpers that Clean Cells

14.08.2018 | Life Sciences

Algorithm provides early warning system for tracking groundwater contamination

14.08.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>