Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

“Allergy cells” can aggravate cancer and psoriasis

11.09.2006
The body’s mast cells are mainly associated with allergic reaction in the way they release histamine and other inflammatory substances. However, researchers at Karolinska Institutet have now demonstrated how the mast cells can also contribute to diseases like psoriasis and cancer.

Mast cells are most known for their association with allergic reactions, as they act like microscopic “bombs” to trigger the release of a number of substances that give rise to the classic allergic symptoms, such as swelling, congestion and itching. The explosive reactions are activated when an allergen (such as pollen particles) binds to receptors on the surface of the mast cell, which then opens and secretes part of its contents.

In the past few years it has emerged that mast cells, which are a type of immune cell, are probably also involved in the development of a number of other diseases, like atopical eczema, psoriasis, and the Hodgkins lymphoma cancer type. These diseases are characterised by chronic inflammations and an increase in the number of mast cells. However, the mechanisms behind this are relatively unknown.

Associate professor Gunner Nilsson at Karolinska Institutet and his research group have now found a possible explanation for the link between mast cells and several non-allergic diseases. The study, which is presented online by The Journal of Clinical Investigation, shows that mast cells can be activated in a previously unknown way that might lead to chronic inflammation.

“These new findings contribute to our understanding of the part played by the mast cell in atopical eczema, psoriasis and Hodgkins Lymphoma,” says Mr Nilsson. “We hope that our research will make it possible for scientists to develop new forms of therapy for the mast cell-related diseases.”

The group discovered that the CD30 protein, which is found on the surface of the immune systems T-lymphocytes amongst other places, can stimulate mast cells to release proteins that regulate the recruitment of inflammatory cells. Since it is already known that levels of CD30 are higher in people with psoriasis or atopical eczema and with Hodgkins lymphoma, the results can explain how the mast cells are activated and how they aggravate inflammation in these diseases.

Katarina Sternudd | alfa
Further information:
http://www.jci.org
http://www.ki.se

More articles from Health and Medicine:

nachricht Why might reading make myopic?
18.07.2018 | Universitätsklinikum Tübingen

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>