Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gelatin Treats Ulcer

24.08.2006
The stomach ulcer of various origins is well prevented and healed by short peptides, which are part of gelatin. The conclusion has been made by the task group combining researchers from the Institute of Molecular Genetics, Russian Academy of Sciences, Faculty of Biology of the Lomonosov Moscow State University and the Shemiakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.

Gelatin’s short peptides - glyprolines – consist of amino acids of glycine and proline. It is them that protect the stomach mucous tunic from injuries. The highest antiulcer activity was discovered by the researchers with the PGP-sequence peptide: proline, glycine, proline. Glyprolines are easily absorbed in the stomach and remain in the blood for a long time without breaking up. They act not only on the stomach cells but also on the central nervous system overcoming the blood-brain barrier, therefore they cure even the ulcers caused by stress.

Glyprolines are natural peptides. They are generated in the organism in the course of collagen synthesis or decomposition. During the experiments carried out by the Moscow biologists, gelatin (partly hydrolyzed collagen) added to rats’ feed partly protected the rats from ulcer. Further experiments were carried out by the researchers with gelatin hydrolysate. Processing gelatin by hydrochloric acid imitates the process taking place in the stomach. After gelatin hydrolysis was performed, the researchers educed and refined about 30 short peptides, also including glyprolines.

It has turned out that gelatin peptides reinforce resistance of the stomach mucous tunic to ethanol and stress action, decreasing the ulcer area by twice. If peptides are introduced to the animals with already developed ulcer, it will also close quicker. Therapeutic effect was revealed by peptides not only in case of intraperitoneal introduction but also in case of intragastric introduction, this method being even more effective.

The researchers point out that gelatin hydrolysate produces protective and medicinal effect comparable to the action of pure PGP peptide, which is currently known as the most active glyproline. In the researchers’ opinion, not only the above-mentioned glyprolines but also short peptides unknown so far participate in the antiulcer action of gelatin peptides. Therefore, to produce the most promising protective and medicinal antiulcer drugs, the researchers are planning to investigate the action of all substances that make part of gelatin hydrolysate.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Distrust of power influences choice of medical procedures
01.08.2018 | Johannes Gutenberg-Universität Mainz

nachricht Research on mutation 'hotspots' in DNA could lead to new insights on cancer risks
31.07.2018 | Indiana University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 26AlF – the first detection of a radioactive molecule in space

The first unambiguous observation of a radioactive molecule, 26AlF, was made in the ancient nova-like object CK Vul (or Nova Vul 1670), which - most likely - is a stellar-merger remnant. The eruption of the object was observed between 1670-1672 in Europe. The interest in this object has been recently rejuvenated by the discovery of molecular gas of a very peculiar isotopic composition in the remnant.
The finding was announced by an international research team led by Tomasz Kamiński (CfA), including Karl Menten (MPIfR Bonn).

The variable star CK Vulpeculae (CK Vul) is known as the location of a stellar outbreak, a nova, which was observed by European astronomers in the 17th century...

Im Focus: Scientists create 'impossible' materials in simple way

Scientists from NUST MISIS and colleagues from the University of Bayreuth, the University of Münster (Germany), the University of Chicago (U.S.), and Linköping University (Sweden) have created nitrides, a material previously considered impossible to obtain. More amazing, they have shown that the material can be obtained using a very simple method of direct synthesis. Articles about the revolutionary research results have been published in Nature Communications and Angewandte Chemie International Edition.

Nitrides are actively used in superhard coatings and electronics. Usually, the nitrogen content in these materials is low, and it is therefore difficult to get...

Im Focus: World-first quantum computer simulation of chemical bonds using trapped ions

An international group of researchers has achieved the world’s first multi-qubit demonstration of a quantum chemistry calculation performed on a system of trapped ions, one of the leading hardware platforms in the race to develop a universal quantum computer.

The research, led by Cornelius Hempel and Thomas Monz, explores a promising pathway for developing effective ways to model chemical bonds and reactions using...

Im Focus: Growing brain cancer in a dish

For the first-time, researchers at IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences – develop organoids, that mimic the onset of brain cancer. This method not only sheds light on the complex biology of human brain tumors but could also pave the way for new medical applications.

Brain tumors are among the most aggressive and deadly cancers and a leading cause of cancer-related death in children and young adults.

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

 
Latest News

UCLA-developed artificial intelligence device identifies objects at the speed of light

03.08.2018 | Information Technology

New lung cell type discovered

03.08.2018 | Life Sciences

Novel PET imaging method could track and guide therapy for type 1 diabetes

03.08.2018 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>