Gelatin’s short peptides - glyprolines – consist of amino acids of glycine and proline. It is them that protect the stomach mucous tunic from injuries. The highest antiulcer activity was discovered by the researchers with the PGP-sequence peptide: proline, glycine, proline. Glyprolines are easily absorbed in the stomach and remain in the blood for a long time without breaking up. They act not only on the stomach cells but also on the central nervous system overcoming the blood-brain barrier, therefore they cure even the ulcers caused by stress.
Glyprolines are natural peptides. They are generated in the organism in the course of collagen synthesis or decomposition. During the experiments carried out by the Moscow biologists, gelatin (partly hydrolyzed collagen) added to rats’ feed partly protected the rats from ulcer. Further experiments were carried out by the researchers with gelatin hydrolysate. Processing gelatin by hydrochloric acid imitates the process taking place in the stomach. After gelatin hydrolysis was performed, the researchers educed and refined about 30 short peptides, also including glyprolines.
It has turned out that gelatin peptides reinforce resistance of the stomach mucous tunic to ethanol and stress action, decreasing the ulcer area by twice. If peptides are introduced to the animals with already developed ulcer, it will also close quicker. Therapeutic effect was revealed by peptides not only in case of intraperitoneal introduction but also in case of intragastric introduction, this method being even more effective.
The researchers point out that gelatin hydrolysate produces protective and medicinal effect comparable to the action of pure PGP peptide, which is currently known as the most active glyproline. In the researchers’ opinion, not only the above-mentioned glyprolines but also short peptides unknown so far participate in the antiulcer action of gelatin peptides. Therefore, to produce the most promising protective and medicinal antiulcer drugs, the researchers are planning to investigate the action of all substances that make part of gelatin hydrolysate.
Nadezda Markina | alfa
Distrust of power influences choice of medical procedures
01.08.2018 | Johannes Gutenberg-Universität Mainz
Research on mutation 'hotspots' in DNA could lead to new insights on cancer risks
31.07.2018 | Indiana University
The first unambiguous observation of a radioactive molecule, 26AlF, was made in the ancient nova-like object CK Vul (or Nova Vul 1670), which - most likely - is a stellar-merger remnant. The eruption of the object was observed between 1670-1672 in Europe. The interest in this object has been recently rejuvenated by the discovery of molecular gas of a very peculiar isotopic composition in the remnant.
The finding was announced by an international research team led by Tomasz Kamiński (CfA), including Karl Menten (MPIfR Bonn).
The variable star CK Vulpeculae (CK Vul) is known as the location of a stellar outbreak, a nova, which was observed by European astronomers in the 17th century...
Scientists from NUST MISIS and colleagues from the University of Bayreuth, the University of Münster (Germany), the University of Chicago (U.S.), and Linköping University (Sweden) have created nitrides, a material previously considered impossible to obtain. More amazing, they have shown that the material can be obtained using a very simple method of direct synthesis. Articles about the revolutionary research results have been published in Nature Communications and Angewandte Chemie International Edition.
Nitrides are actively used in superhard coatings and electronics. Usually, the nitrogen content in these materials is low, and it is therefore difficult to get...
An international group of researchers has achieved the world’s first multi-qubit demonstration of a quantum chemistry calculation performed on a system of trapped ions, one of the leading hardware platforms in the race to develop a universal quantum computer.
The research, led by Cornelius Hempel and Thomas Monz, explores a promising pathway for developing effective ways to model chemical bonds and reactions using...
For the first-time, researchers at IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences – develop organoids, that mimic the onset of brain cancer. This method not only sheds light on the complex biology of human brain tumors but could also pave the way for new medical applications.
Brain tumors are among the most aggressive and deadly cancers and a leading cause of cancer-related death in children and young adults.
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
27.07.2018 | Event News
25.07.2018 | Event News
13.07.2018 | Event News
03.08.2018 | Information Technology
03.08.2018 | Life Sciences
03.08.2018 | Medical Engineering