Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Urine test helps detect 99 percent of recurring bladder cancers

18.01.2006


Results available in physician’s office

A simple urine test that can be interpreted in a doctor’s office can help detect nearly all recurrences of bladder cancers with a higher accuracy rate than conventional laboratory analysis of urine tests. The BladderChek test, used in conjunction with a diagnostic scope, detected 99 percent of recurring bladder cancers, according to a study in the Jan. 18 issue of JAMA.

"This is good news for patients. If you have been treated for bladder cancer and are being monitored for recurrence, the accuracy of your diagnosis is extremely important. We depend on the urine test to show us whether there’s a possibility of cancer that we’re not seeing with the scope. If we say there’s no recurrence of cancer, we want to be right," says author Barry Stein, MD, a professor of urology at Brown Medical School and surgeon-in-chief of urology at Rhode Island Hospital, a participating site in the study.



The BladderChek test – which requires four drops of urine – detects elevated levels of the nuclear matrix protein NMP22, an indication of cancer even at early stages of the disease. A doctor or nurse can read the results in 30 to 50 minutes.

"You know the answer before the patient is out of your office," Stein says. "If the result is positive, and you didn’t see anything from the cystoscopy, you would check to see if you missed something."

No single procedure is completely effective in detecting recurring bladder cancer, so physicians use a combination of methods – typically cystoscopy and a urine cytology test. Cystoscopy, a minimally invasive procedure performed in a physician’s office, enables physicians to view the wall of the bladder through a scope. However, it may not detect very small tumors or tumors in the muscle or upper tract. So in conjunction with the scope, physicians rely on cytology, a clinical analysis of a urine sample. The process can take a week or more, and requires expert interpretation. The analysis identifies changes in intact cells, but its sensitivity is dependent on the size and shape of the tumor.

In this study, 668 patients with a history of bladder cancer provided a urine sample before undergoing cystoscopy during follow-up visits with their physician. The urine sample was analyzed with urine cytology, and with the BladderChek test. Bladder cancer was identified in 103 patients. Cytoscopy alone detected 94 cancers, and the BladderChek test detected 8 of 9 cancers that were not seen through the scope – 7 of them life-threatening. The urine cytology only detected 3 of the 9 cancers.

Cystoscopy alone detected 91.3 percent of cancers. When cystoscopy was used with conventional urine analysis, the detection rate was 94.2 percent; when it was used with the BladderChek test, detection was 99 percent.

An accurate urine test could reduce the number of cystoscopies a patient undergoes, Stein says. While not painful, the procedure can be uncomfortable. By contrast, the BladderChek test is similar to a pregnancy test and gives objective results – if cancer is detected, a purple line appears.

The study demonstrates that one day a simple urine test might replace cystoscopies, Stein says.

"I’m not saying any one study gives you the confidence to change 100 years of tradition," Stein says. "We need to do further research. But if a test is developed that is effective as a stand-alone, that would be a real benefit."

Nicole Gustin | EurekAlert!
Further information:
http://www.lifespan.org

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>