Researchers have discovered that drugs, such as heart burn medications, which reduce gastric acidity, are potential risk factors for Clostridium difficile infection outside of hospitals. The new research to be published in the Journal of the American Medical Association (JAMA) tomorrow focuses on community-acquired C. difficile, and is a follow-up to previous work by the same group that demonstrated an increased risk from these medications in hospital settings.
"We believe drugs that reduce gastric acidity provide a more hospitable environment within which C. difficile bacteria can colonize," says MUHC researcher and lead author of the new study Dr. Sandra Dial. Numerous studies worldwide have documented increases in hospital C. difficile associated disease, but this study is the first to suggest this trend is mirrored in the general community. Dr. Sandra Dial is Attending Staff in the Department of Critical Care at both the MUHC and Jewish General Hospital (JGH) and an Assistant Professor of Medicine at McGill University.
Using data from the United Kingdom General Practice Research Database (GPRD), researchers traced variation in community C. difficile associated disease over a 10-year period. "In 1994 there was less than one C. difficile case per 100,000 people in the database," says Dr. Dial. "By 2004, this number had increased exponentially to 22 cases to per 100,000." It is important to note however, that community rates are still much lower than hospitals overall.
Ian Popple | EurekAlert!
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences