Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Ovarian Cancer Risk and Consumption of Milk Products and Lactose

05.08.2005


Meta-Analysis of Epidemiological Studies Finds Some Support for a Link



An analysis of 21 studies that have investigated the link between ovarian cancer and the consumption of milk products and lactose has found some support for the hypothesis that high intake is associated with increased cancer risk. The results of this analysis, published online August 5, 2005 in the International Journal of Cancer, the official journal of the International Union Against Cancer (UICC), found that support was stronger in cohort studies, compared to case-control studies, which offered varying results.

Since a positive correlation between ovarian cancer risk and the consumption of milk products and lactose was first reported in 1989, many epidemiological studies have further examined the relationship. However, these studies have yielded conflicting conclusions. To better understand the uncertain relationship, researchers led by Susanna C. Larsson of the National Institute of Environmental Medicine at the Karolinska Institute in Sweden, conducted a meta-analysis of relevant case-control and cohort studies.


The researchers sought reports that offered data from a case-control, or cohort study on the association between intakes of milk, yogurt, cheese or lactose, and incidence of or mortality from epithelial ovarian cancer. Studies also had to present results as an odds ratio, or relative risk, with 95 percent confidence intervals. The researchers accepted three prospective cohort studies, and 18 case-control studies and performed a meta-analysis to determine associations between consumption and cancer risk.

Their analysis found notable differences between case-control and cohort studies. Case-control studies showed low-fat milk consumption negatively associated, and whole milk consumption positively associated, with the risk of ovarian cancer, but offered no support for the involvement of lactose in the development of ovarian cancer. By contrast, prospective cohort studies indicated that high intakes of milk may increase the risk of ovarian cancer. They also revealed a 13 percent increase in ovarian cancer risk with a daily increase of 10 grams of lactose, the approximate amount in one glass of milk. When case-control and cohort studies were considered in combination, yogurt consumption was associated with a non-significant increase in cancer risk, while cheese was not associated with risk.

The differences between the findings of case-control studies and those of cohort studies could be explained by a number of factors: selection bias, recall bias or changes in dietary practices after cancer diagnosis. They might also be due to the time interval between diet assessment and illness, since cohort studies may record dietary practices decades before illness occurs, while case-control studies assess diet around the time of diagnosis. Other limitations of this study include the observational nature of the assessed studies, imprecise measurements of diet, and publication bias.

Of note, the two studies that examined histological subtypes of ovarian cancer found that the associations with milk and lactose intakes were confined to serous ovarian cancer, leading researchers to advise, “future studies should consider specific subtypes of ovarian cancer, and the interrelationship between intakes of dairy foods and lactose, genetic polymorphisms, and ovarian cancer risk.”

“In conclusion,” they write, “prospective cohort studies, but not case-control studies, support the hypothesis that high intakes of dairy foods and lactose may increase the risk of ovarian cancer.”

Polly Young | alfa
Further information:
http://www.interscience.wiley.com/journal/ijc.

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>