French scientists, examining the possibility of using nuclear medicine with gene therapy to fight heart diseases, reported their findings at the Society of Nuclear Medicines 52nd Annual Meeting June 18–22 in Toronto.
Previous studies have suggested a beneficial effect of Cyr61--a cysteine-rich, angiogenic inducer protein--in rabbits submitted to ischemic limb disease. However, no data have been available on using Cyr61 in vivo for fighting chronic myocardial ischemia (insufficient blood flow and oxygen to the heart muscle).
"Cyr61 gene transfer appears potent in stimulation of myocardial angiogenesis--a novel gene therapeutic approach that seeks to induce the growth of new blood vessels in areas of the heart that are not sufficiently supplied by blood due to severe coronary artery disease," said Pascal Merlet, M.D., Ph.D., nuclear medicine department, Hopital Bichat, Paris, France. "Our findings suggest that Cyr61 could be a therapeutic candidate for treating severe myocardial ischemic disease," he added. The French scientists examined Cyr61s effect in a porcine model of ischemic heart disease.
Maryann Verrillo | EurekAlert!
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