Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

ALLHAT findings are ’color blind’ in showing diuretics work better for high blood pressure

06.04.2005


Three University of Texas School of Public Health at Houston faculty members are co-authors of an article in the April 6 issue of The Journal of the American Medical Association. The article reports study results suggesting older, cheaper diuretics remain the drug of choice for both black and non-black patients in treating high blood pressure and reducing risk of heart disease.



The analysis by race of the "Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial" (ALLHAT), confirms earlier findings that diuretics rather than newer, more expensive drugs such as ACE inhibitors, calcium channel blockers, or beta blockers should be preferred as a first therapy for most patients.

The multi-center ALLHAT study is conducted under a National Institutes of Health contract with The University of Texas Health Science Center at Houston. Barry R. Davis, M.D., Ph.D., professor of biostatistics in the UT School of Public Health is the Principal Investigator and a co-author of the JAMA article.


"There was question whether the diuretics’ success with hypertension applied by race because black patients have less success than non-black patients with the ACE inhibitors," said Davis, who also is director of the Coordinating Center for Clinical Trials at the UT School of Public Health. "However the results showed diuretics were as good or better than the newer drugs regardless of race."

The study concludes that diuretics are similar to or superior to newer drugs in lowering blood pressure, in tolerability and in preventing the major complications from high blood pressure. Across both racial subgroups, there was substantially higher risk of heart failure--37 percent--among participants taking calcium channel blockers compared with those on diuretics. When compared to ACE inhibitors, diuretics were more effective in preventing cardiovascular disease, especially heart failure, for all participants and significantly more effective in reducing high blood pressure and preventing stroke in blacks.

"These findings confirm ALLHAT’s original conclusion that diuretics should be the preferred initial therapy for high blood pressure," Davis said.

Melanie Hillis | EurekAlert!
Further information:
http://www.uth.tmc.edu

More articles from Health and Medicine:

nachricht Researchers image atomic structure of important immune regulator
11.12.2018 | Brigham and Women's Hospital

nachricht Potential seen for tailoring treatment for acute myeloid leukemia
10.12.2018 | University of Washington Health Sciences/UW Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

Im Focus: Substitute for rare earth metal oxides

New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals

Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.

Im Focus: A bit of a stretch... material that thickens as it's pulled

Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.

Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Expert Panel on the Future of HPC in Engineering

03.12.2018 | Event News

 
Latest News

Electronic evidence of non-Fermi liquid behaviors in an iron-based superconductor

11.12.2018 | Physics and Astronomy

Topological material switched off and on for the first time

11.12.2018 | Materials Sciences

NIST's antenna evaluation method could help boost 5G network capacity and cut costs

11.12.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>