Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Serum sodium level is a major predictor of a poor prognosis for heart failure patients

09.03.2005


Findings presented at ACC Scientific Sessions show improving serum sodium levels may improve outcomes



Research presented on Monday at the American College of Cardiology’s Scientific Sessions in Orlando pinpoints a major marker of a poor prognosis for heart failure, hyponatremia, or a lower than normal concentration of serum or blood sodium. Researchers found that hyponatremia, which is found in almost a quarter of patients with severe heart failure, doubled death rates within 60 days of hospital discharge. Serum sodium levels are easily measured through routine blood tests.

"Even a minor decrease in a person’s serum sodium level – levels that are now dismissed by physicians – had a major impact on mortality of heart failure patients," says Mihai Gheorghiade, MD, associate chief, Division of Cardiology, Northwestern Memorial Hospital and Northwestern University Feinberg School of Medicine, and lead presenter of the findings from the ESCAPE trial during a poster session on Monday.


Heart failure is a major health threat in this country, resulting in 1 million hospital admissions each year. "These findings illustrate that not all heart failure is created equally – heart failure accompanied with hyponatremia is especially dangerous. Levels of serum sodium may prove a useful and easily accessible risk assessment tool in the clinical management of patients hospitalized for heart failure," says Dr. Gheorghiade.

The good news is that a separate study presented Monday by Dr. Gheorghiade showed that improvement in sodium serum levels during hospitalization was associated with improved outcomes. In the ACTIV trial, patients with a serum sodiuim improvement at hospital discharge had a 15.6 percent mortality rate at 60 days post discharge, compared with a 30.4 percent mortality rate in those showing no improvement. "Currently, the medical community is not paying much attention to serum sodium levels in heart failure patients. However, serum sodium appears to be a modifiable target that can be treated," says Dr. Gheorghiade.

A paper authored by Dr. Gheorghiade and published in JAMA in April of 2004 found that the medication tolvaptan was a promising addition to standard therapy for patients hospitalized with heart failure. In addition to reducing fluid buildup and decreasing body weight, tolvaptan improved serum sodium levels in patients with hyponatremia. "This is important because previously, we have not had very effective therapies for treating hyponatremia in patients with heart failure. Now, we think it can be treated, and we have an understanding that treating it can make a huge difference for the patient," says Dr. Gheorghiade.

Sodium is an electrolyte that helps with nerve and muscle function, and also helps to maintain blood pressure. Hyponatremia most commonly occurs in people whose kidneys do not function properly, as well as in those with heart failure, cirrhosis of the liver, and Addison’s disease. Sodium must be maintained at a specific concentration in the blood and the fluid surrounding the body’s cells for the body to function properly.

Amanda Widtfeldt | EurekAlert!
Further information:
http://www.nmh.org

More articles from Health and Medicine:

nachricht The cytoskeleton of neurons has been found to be involved in Alzheimer's disease
18.01.2019 | University of the Basque Country

nachricht Bioinspired nanoscale drug delivery method developed by WSU, PNNL researchers
10.01.2019 | Washington State University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Ten-year anniversary of the Neumayer Station III

The scientific and political community alike stress the importance of German Antarctic research

Joint Press Release from the BMBF and AWI

The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...

Im Focus: Ultra ultrasound to transform new tech

World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles

The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.

Im Focus: Flying Optical Cats for Quantum Communication

Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.

In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...

Im Focus: Nanocellulose for novel implants: Ears from the 3D-printer

Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.

It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:

Im Focus: Elucidating the Atomic Mechanism of Superlubricity

The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.

One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Our digital society in 2040

16.01.2019 | Event News

11th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Aachen, 3-4 April 2019

14.01.2019 | Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

 
Latest News

Additive manufacturing reflects fundamental metallurgical principles to create materials

18.01.2019 | Materials Sciences

How molecules teeter in a laser field

18.01.2019 | Life Sciences

The cytoskeleton of neurons has been found to be involved in Alzheimer's disease

18.01.2019 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>