Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

CAD Detects Breast Cancers That Are Most Challenging to Detect

04.03.2005


A computer-aided detection system (CAD) can effectively detect breast cancers a radiologist is more apt to initially miss, a new study shows.



Small lesions are very challenging for the radiologist to detect, said Rachel F. Brem, MD, director of breast imaging at George Washington University in Washington, DC, and lead author of the study. The study of 201 women found that CAD was “highly effective in detecting even the smallest lesions, with a sensitivity of 92% for lesions of 5 mm or less,” said Dr. Brem. CAD was most effective in detecting cancers measuring 11-15 mm (94%) and least effective in detecting cancers measuring 16-20 mm (80%), Dr. Brem said. Lesion size is important; “cancers smaller than or equal to 1 cm have a better prognosis than cancers greater than 1 cm,” she said.

Subtle masses are also difficult to detect, Dr. Brem said. The study found that CAD had a sensitivity of 83% for the smallest masses (those measuring 1-5 mm). It was most sensitive for masses 11-15 mm (91%) and least sensitive for larger masses measuring greater than 20 mm (75%).


CAD systems assist the radiologist by “processing the breast films, using algorithms to detect suspicious areas and highlighting those areas,” said Dr. Brem. This study shows that CAD can help in the most difficult-to-detect cases. CAD prompts the radiologist to re-examine the films, and the radiologist decides whether “true areas of concern are present at the highlighted locations before making the final diagnosis,” she said.

The study also looked at the false-positive mark rate, i.e. the number of areas CAD highlighted that were not cancers. “A large number of false-positive marks can significantly hinder the usefulness of CAD by distracting the interpreting radiologist,” Dr. Brem said. However, “our study showed 1.3 false-positive marks per image, a reasonable number that should not affect the radiologists interpretation, nor should it mean that more women would be called back for additional mammograms,” Dr. Brem said.

CAD is “a useful tool for the improved detection of breast cancer. Based on this study, CAD could reduce the number of missed cancers, as well as positively impact breast cancer prognosis, without increasing the patient recall rate or the physician’s workload,” Dr. Brem said.

The study appears in the March 2005 issue of the American Journal of Roentgenology.

Jason Ocker | EurekAlert!
Further information:
http://www.arrs.org

More articles from Health and Medicine:

nachricht New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute

nachricht Distrust of power influences choice of medical procedures
01.08.2018 | Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

Im Focus: World record: Fastest 3-D tomographic images at BESSY II

The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.

Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...

Im Focus: A molecular switch may serve as new target point for cancer and diabetes therapies

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz- Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases. The results of the study have just been published in the prestigious scientific journal 'Molecular Cell'.

Cell growth and cell differentiation as well as the release and efficacy of hormones such as insulin depend on the presence of lipids. Lipids are small...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

NRL's sun imaging telescopes fly on NASA Parker Solar Probe

13.08.2018 | Physics and Astronomy

UT-ORNL team makes first particle accelerator beam measurement in six dimensions

13.08.2018 | Physics and Astronomy

ASU astrophysicist helps discover that ultrahot planets have starlike atmospheres

13.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>