Previous research has implicated the brain’s opioid system in the development of alcohol-use disorders. The mu-opioid receptor, which is encoded by the OPRM1 gene, is the primary site of action for opiates with high abuse potential, such as opium and heroin, and may also contribute to the effects of non-opioid drugs, such as cocaine and alcohol. Findings published in the December issue of Alcoholism: Clinical & Experimental Research indicate that individuals with the G variant of the A118 polymorphism of the OPRM1 gene have greater subjective feelings to alcohol’s effects as well as a greater likelihood of a family history of alcohol-use disorders.
"Alcohol releases endogenous opiates which, in turn, seem to influence the mesolimbic dopamine system," said Kent E. Hutchison, associate professor of psychology at the University of Colorado at Boulder and lead author of the study. "This system is involved in craving and the motivation to use alcohol and drugs. Thus, it is alcohol’s effects on endogenous opioids that act as the gateway through which alcohol may influence this system."
"It is well known that alcohol dependence tends to run in families," said Robert Swift, professor of psychiatry and human behavior at Brown University and Associate Chief of Staff for Research at the Providence VA Medical Center. "The inheritance of alcoholism is complex, but there are suggestions that the opiate systems in the brain are involved. Our brains contain proteins, called enkephalins and endorphins, that act like morphine and other opiates derived from the poppy plant. Several researchers have shown that persons with a family history of alcoholism tend to have differences in blood levels of beta-endorphin, a natural opiate hormone, compared to persons without a family history of alcoholism. Children of alcoholics, who are not themselves alcoholics, have lower levels of beta-endorphin than do children of non-alcoholics. Also, when young adults with a family history of alcoholism drink alcohol, they increase their blood levels of beta-endorphin more than those without a family history of alcoholism."
Inselspital: Fewer CT scans needed after cerebral bleeding
20.03.2019 | Universitätsspital Bern
Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz
Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.
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Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.
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The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.
A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...
Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.
"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...
New research group at the University of Jena combines theory and experiment to demonstrate for the first time certain physical processes in a quantum vacuum
For most people, a vacuum is an empty space. Quantum physics, on the other hand, assumes that even in this lowest-energy state, particles and antiparticles...
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