Fibrin gel matrix-based vessel ready for test transplantation after only two weeks in culture
The search for a stable, renewable source of blood vessels, especially for potential use in heart bypass surgery, has reached a milestone at the State University of New York at Buffalo. A multi-disciplinary team at SUNY Buffalo designed tissue engineered blood vessels (TEVs) using a matrix of vascular smooth muscle embedded in fibrin gels. After only two weeks in culture, the TEVs showed the strength and resiliency necessary for implantation. Even more exciting, 15 weeks after implantation, the fibrin-based TEVs "exhibited remarkable remodeling with considerable production of collagen and elastin, and significantly increased mechanical strength (and) physiological levels of blood flow and vasoreactivity," according to a paper published online in the American Journal of Physiology-Heart and Circulatory Physiology.
Currently, blood vessels are usually "harvested" from the patient’s own leg, often causing pain and discomfort, as well as extra surgical steps. So the need for a source of strong, yet elastic -- and physiologically responsive – replacement blood vessels has been the subject of laboratory searches and experimentation for decades.
Mayer Resnick | EurekAlert!
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For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
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Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
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