In the largest known study of its kind, scientists have confirmed that men with high grade prostatic intraepithelial neoplasia or PIN, characterized by abnormal cells in the lining of prostate ducts, are at high risk for invasive prostate cancer. The study, presented today at the American Association for Cancer Research Third Annual International Conference on Frontiers in Cancer Prevention Research, showed that about one in three men with high grade PIN are at high risk for prostate cancer within a year of detection and should be closely monitored for disease progression.
"This study confirms that the increased risk factor associated with high-grade PIN is real and not just a coincidence," said Dr. Mitchell S. Steiner, chief executive officer with GTx, Inc. "The next step is to develop an effective therapy for treating high grade PIN, before prostate cancer has a chance to take root. We know that there is a measurable window of opportunity for treatment before the cancer appears. "We must take advantage of that opportunity as a key step toward prostate cancer prevention."
In this prospectively designed study, some 109 men with high-grade PIN and no prostate cancer at baseline were analyzed. In addition to the baseline biopsy, patients were re-biopsied at six and 12 months to test for the presence of prostate cancer. Results demonstrate that within one year, men in the placebo group had a 31.4 percent risk of being diagnosed with prostate cancer.
Angela DeCicco | EurekAlert!
Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering
New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center
Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.
Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
18.12.2018 | Materials Sciences
18.12.2018 | Physics and Astronomy
18.12.2018 | Physics and Astronomy