In this retrospective study, eighty-eight patients with advanced hepatocellular carcinoma (HCC) were treated with long-term chemotherapy infusion into the hepatic artery, the main artery that supplies the liver. Known as hepatic arterial chemotherapy, this treatment requires a reservoir/pump system to supply the drug directly to the liver and the liver cancer. The reservoir port systems currently available have to be surgically implanted, making this treatment unavailable to many patients who were unable or unwilling to have the implant. Interventional radiologists -- vascular experts who are uniquely skilled in using the vascular system to deliver targeted treatments via catheter throughout the body -- adapted conventional venous ports to use in the arterial circulation. In this method, the interventional radiologist implanted the reservoir and then embolized – mechanically blocked – the arteries to the adjacent areas during the port placement to prevent the influx of drugs to areas outside of the liver. This is beneficial because the chemotherapy drug is only circulated to the organ with the cancer, so the drug does not harm healthy tissue throughout the body. This allows for a higher dose of chemotherapy drug to be used, because the drug is contained.
Hepatic Arterial Infusion Chemotherapy
The hepatic arterial infusion chemotherapy was initiated after reservoir implantation on an outpatient basis. The infusion protocols were decided for each patient by the physician in charge and chemotherapeutic agents were administered every 1–4 weeks. In 55 patients, cisplatin (10 mg/m2) and 5-fluorouracil (1,000 mg/m2) were given at 1 hour and 5 hours, respectively. In the other 33 patients, doxorubicin hydrochloride or epirubicin hydrochloride (10–20 mg/m2) were injected every 2–4 weeks in a "one-shot" manner.
Nitric oxide-scavenging hydrogel developed for rheumatoid arthritis treatment
06.06.2019 | Pohang University of Science & Technology (POSTECH)
Infants later diagnosed with autism follow adults’ gaze, but seldom initiate joint attention
24.05.2019 | Schwedischer Forschungsrat - The Swedish Research Council
Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.
Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...
Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.
The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...
Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.
The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....
Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.
Photonics is concerned with various means of using light. Fibre-optic communication is an example of photonics, as is the technology behind photodetectors and...
Fraunhofer IZM is joining the EUROPRACTICE IC Service platform. Together, the partners are making fan-out wafer level packaging (FOWLP) for electronic devices available and affordable even in small batches – and thus of interest to research institutes, universities, and SMEs. Costs can be significantly reduced by up to ten customers implementing individual fan-out wafer level packaging for their ICs or other components on a multi-project wafer. The target group includes any organization that does not produce in large quantities, but requires prototypes.
Research always means trying things out and daring to do new things. Research institutes, universities, and SMEs do not produce in large batches, but rather...
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