A new study has found a possible mechanism for tamoxifen resistance in breast cancer and provides evidence that another cancer drug--gefitinib (Iressa)--may be able to restore tamoxifens anticancer activity. The study appears in the June 16 issue of the Journal of the National Cancer Institute.
Although adjuvant tamoxifen can reduce the risk of death for women with invasive breast cancer by about 15% over 10 to 15 years, many women do not receive any benefit from the drug. Even among patients most likely to benefit from tamoxifen--those with tumors that express the drugs target, the estrogen receptor (ER)--only 40% to 50% actually benefit. Studies have shown that patients with ER-positive tumors that express high levels of HER2/neu and the ER coactivator AIB1 often develop tamoxifen resistance, but the mechanism of the resistance has not been identified.
To find this mechanism, Rachel Schiff, Ph.D. and C. Kent Osborne, M.D., of the Baylor College of Medicine in Houston, and colleagues studied molecular interactions in breast cancer cells that expressed high levels of both HER2 and AIB1. They found that, in these cells, tamoxifen acted like an estrogen agonist and stimulated tumor growth. However, when the breast cancer cells were treated with the receptor tyrosine kinase inhibitor gefitinib, tamoxifen once again acted as an estrogen antagonist and tumor growth was blocked.
Sarah L. Zielinski | EurekAlert!
Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering
New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center
Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.
Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
18.12.2018 | Materials Sciences
18.12.2018 | Physics and Astronomy
18.12.2018 | Physics and Astronomy