A new study has found a possible mechanism for tamoxifen resistance in breast cancer and provides evidence that another cancer drug--gefitinib (Iressa)--may be able to restore tamoxifens anticancer activity. The study appears in the June 16 issue of the Journal of the National Cancer Institute.
Although adjuvant tamoxifen can reduce the risk of death for women with invasive breast cancer by about 15% over 10 to 15 years, many women do not receive any benefit from the drug. Even among patients most likely to benefit from tamoxifen--those with tumors that express the drugs target, the estrogen receptor (ER)--only 40% to 50% actually benefit. Studies have shown that patients with ER-positive tumors that express high levels of HER2/neu and the ER coactivator AIB1 often develop tamoxifen resistance, but the mechanism of the resistance has not been identified.
To find this mechanism, Rachel Schiff, Ph.D. and C. Kent Osborne, M.D., of the Baylor College of Medicine in Houston, and colleagues studied molecular interactions in breast cancer cells that expressed high levels of both HER2 and AIB1. They found that, in these cells, tamoxifen acted like an estrogen agonist and stimulated tumor growth. However, when the breast cancer cells were treated with the receptor tyrosine kinase inhibitor gefitinib, tamoxifen once again acted as an estrogen antagonist and tumor growth was blocked.
Sarah L. Zielinski | EurekAlert!
Skipping Meat on Occasion May Protect Against Type 2 Diabetes
25.06.2019 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
Inhaling air pollution-like irritant alters defensive heart-lung reflex for hypertension
19.06.2019 | University of South Florida (USF Innovation)
From June 25th to 27th 2019, the Fraunhofer Institute for Digital Media Technology IDMT in Ilmenau (Germany) will be presenting a new solution for acoustic quality inspection allowing contact-free, non-destructive testing of manufactured parts and components. The method which has reached Technology Readiness Level 6 already, is currently being successfully tested in practical use together with a number of industrial partners.
Reducing machine downtime, manufacturing defects, and excessive scrap
The quality of additively manufactured components depends not only on the manufacturing process, but also on the inline process control. The process control ensures a reliable coating process because it detects deviations from the target geometry immediately. At LASER World of PHOTONICS 2019, the Fraunhofer Institute for Laser Technology ILT will be demonstrating how well bi-directional sensor technology can already be used for Laser Material Deposition (LMD) in combination with commercial optics at booth A2.431.
Fraunhofer ILT has been developing optical sensor technology specifically for production measurement technology for around 10 years. In particular, its »bd-1«...
The well-known representation of chemical elements is just one example of how objects can be arranged and classified
The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...
Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.
Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...
Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.
The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...
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25.06.2019 | Health and Medicine